Evidence map›Paper›PMID 32701168›Full record

ArticleAlcoholism, clinical and experimental research2020

Subtypes of Alcohol Dependence and 36-Year Mortality.

Michie N Hesselbrock, Victor M Hesselbrock, Grace Chan, Frances Del Boca, Karen Chartier

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michie N HesselbrockFrom the, Department of Psychiatry MC-2103, (MNH, VMH, GC), University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Victor M HesselbrockFrom the, Department of Psychiatry MC-2103, (MNH, VMH, GC), University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-0495-8641
Grace ChanFrom the, Department of Psychiatry MC-2103, (MNH, VMH, GC), University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-1257-6889
Frances Del BocaDepartment of Public Health Sciences MC-6325, (FDB), University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Karen ChartierSchool of Social Work, (KC), Virginia Commonwealth University, Richmond, Virginia, USA.
University of Connecticut · USVirginia Commonwealth University · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI BERNICE PORJESZ · 1989 to 2026
$162.7M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
PSYCHOPHARMACOLOGY--ORAL ALCOHOL CHALLENGE/ALCOHOL CLAMPINGU10AA008403 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI BEGLEITER, HENRI · 1989 to 2003
$23.7M
Vulnerabilities for coping-related drinking among post-college young adultsP60AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 2008 to 2017
$17.5M
WHO COLLABORATIVE PROJECT ON MANAGEMENT OF HARMFUL ALCOHOL CONSUMPTIONP50AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 1985 to 2007
$13.6M
Pilot StudiesP50AA027055 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOLZHAUER, CATHRYN GLANTON, STEFFENS, DAVID C. · 2019 to 2023
$7.8M
NIAAA NIH HHS 5P60-AA03510NIAAA NIH HHS P50 AA003510NIAAA NIH HHS P50 AA027055NIAAA NIH HHS P60 AA003510NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U-10-AA08403NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

backgroundChronic, heavy alcohol use is associated with multiple health problems, including premature death. Further, the clinical presentation of alcohol dependence may differentially affect and predict the long-term health consequences of affected individuals. Subtypes of alcohol dependence based upon treatment intake information can help identify homogenous groups of patients for treatment purposes, but have not been used to predict long-term outcomes. The current study examined mortality in a 36-year posttreatment interval among 4 subtypes of alcohol-dependent patients based upon their initial intake data.

methodsExtensive baseline data were collected from n = 316 male and female patients receiving inpatient treatment for alcohol dependence between 1980 and 1982. Four alcohol dependent subtypes (Del Boca & Hesselbrock, Alcohol Health Res World, 20:56, 1996) derived from the baseline data were used to examine the 1-year posttreatment drinking status and the risk of death 36 years postdischarge. Public records were used to determine patient deaths in the 36 years since discharge.

resultsAt the 36-year follow-up interval since discharge, 68.4% of the sample had died. The 4 subtypes were found to be associated with different rates of resumption of regular drinking in the first year posttreatment and a differential risk of mortality. An increased risk for returning to regular drinking (once a week or more) and early death were associated with subtypes defined, in part, by conduct problems and externalizing disorders. Regardless of subtype membership, women had the highest risk of death following treatment.

conclusionsThis study demonstrates the clinical usefulness of subtypes of alcohol dependence for examining different alcohol use outcomes, including predicting mortality. The increased risks for returning to regular drinking once a week or more and early death posttreatment among subtypes associated with conduct problems and externalizing disorders suggest the need for continued monitoring and possible additional intervention postdischarge.

Indexed as

MortalityAdultAlcoholismAntisocial Personality DisorderAnxiety DisordersComorbidityConduct DisorderDepressive DisorderFemaleHumansLongitudinal StudiesMaleMiddle AgedSex FactorsYoung AdultAlcohol DependenceFollow-UpMortalityTypology

Identifiers

PMID32701168
PMCPMC8221267
OpenAlexW3044047741

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.