Evidence map›Paper›PMID 32700828›Full record

Trial reportBrain and behavior2020

Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.

Gunes Sevinc, Jonathan Greenberg, Britta K Hölzel, Tim Gard, Thomas Calahan, Vincent Brunsch, Javeria A Hashmi, Mark Vangel, Scott P Orr, Mohammed R Milad and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  13. Sleep, Cognition, and Yoga.International journal of yoga
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gunes SevincDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9282-0230
Jonathan GreenbergDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Britta K HölzelDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tim GardDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Thomas CalahanDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Vincent BrunschDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Javeria A HashmiDepartment of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
Mark VangelDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Scott P OrrDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mohammed R MiladPsychiatry Department, New York University Grossman School of Medicine, New York, NY, USA.
Sara W LazarDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Neural and cognitive changes associated with mindfulness training in older adultsR01AG048351 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, LAZAR, SARA W · 2015 to 2019
$4.0M
Structural, Functional, and Behavioral Effects of MeditationR01AT006344 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI LAZAR, SARA W · 2011 to 2015
$2.2M
Exploratory Analysis of RR and MBSR for Stress ReductionR21AT003425 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI LAZAR, SARA W · 2007 to 2008
$896k
NCCIH NIH HHS R01 AT006344NCCIH NIH HHS R21 AT003425NIA NIH HHS R01 AG048351
6 · The paper itself

Abstract

introductionMindfulness meditation has successfully been applied to cultivate skills in self-regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory experience has been postulated to create an optimal therapeutic exposure condition and thereby improve extinction learning. We recently demonstrated increased connectivity in hippocampal circuits during the contextual retrieval of extinction memory following mindfulness training.

methodsHere, we examine the role of structural changes in hippocampal subfields following mindfulness training in a randomized controlled longitudinal study using a two-day fear-conditioning and extinction protocol.

resultsWe demonstrate an association between mindfulness training-related increases in subiculum and decreased hippocampal connectivity to lateral occipital regions during contextual retrieval of extinguished fear. Further, we demonstrate an association between decreased connectivity and decreases in self-reported anxiety following mindfulness training.

conclusionsThe results highlight the role of the subiculum in gating interactions with contextual stimuli during memory retrieval and, also, the mechanisms through which mindfulness training may foster resilience.

Indexed as

MindfulnessAnxietyHippocampusHumansLongitudinal StudiesSelf Reportextinctionextinction retrievalfear memoryfMRIhippocampusmindfulnesssubiculum

Identifiers

PMID32700828
PMCPMC7507558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.