Evidence map›Paper›PMID 32700664›Full record

ArticleThe American journal of tropical medicine and hygiene2020

The Origin of COVID-19 and Why It Matters.

David M Morens, Joel G Breman, Charles H Calisher, Peter C Doherty, Beatrice H Hahn, Gerald T Keusch, Laura D Kramer, James W LeDuc, Thomas P Monath, Jeffery K Taubenberger

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. A Systematic Review of Joint Spatial and Spatiotemporal Models in Health Research.International journal of environmental research and public health · 2023
    Pooled it
  2. Coronavirus Disease 2019 Vaccination for Cancer Patients: Risk or Benefit?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

David M Morens1American Committee on Arthropod-Borne Viruses, American Society of Tropical Medicine and Hygiene, Arlington, Virginia.
Joel G Breman3American Society of Tropical Medicine and Hygiene, Arlington, Virginia.
Charles H Calisher4Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology & Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
Peter C Doherty5Department of Microbiology and Immunology, University of Melbourne at the Doherty Institute, Melbourne, Australia.
Beatrice H Hahn6Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Gerald T Keusch8Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Laura D Kramer11Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York.
James W LeDuc13Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.
Thomas P Monath3American Society of Tropical Medicine and Hygiene, Arlington, Virginia.
Jeffery K Taubenberger15Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
National Institute of Allergy and Infectious Diseases · USAmerican Society of Tropical Medicine and Hygiene · USBoston University · USColorado State University · USCrozet BioPharma (United States) · USThe University of Texas Medical Branch at Galveston · USUniversity of Melbourne · AUUniversity of Pennsylvania · USWadsworth Center · US

Funding

Optimizing glycan shield coverage, germline B cell receptor binding and epitope diversity of V2-apex targeted HIV-1 Env immunogensR37AI150590 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Beatrice H Hahn · 2019 to 2026
$6.9M
Natural SIV Reservoirs and Human Zoonotic RiskR01AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2001 to 2022
$6.1M
SARS-CoV-2 PathogenesisZIAAI001271 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TAUBENBERGER, JEFFERY · 2020 to 2025
$3.1M
NIAID NIH HHS R01 AI050529NIAID NIH HHS R37 AI150590
6 · The paper itself

Abstract

The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its emergence in humans remains unknown. Nevertheless, a large body of virologic, epidemiologic, veterinary, and ecologic data establishes that the new virus, SARS-CoV-2, evolved directly or indirectly from a β-coronavirus in the sarbecovirus (SARS-like virus) group that naturally infect bats and pangolins in Asia and Southeast Asia. Scientists have warned for decades that such sarbecoviruses are poised to emerge again and again, identified risk factors, and argued for enhanced pandemic prevention and control efforts. Unfortunately, few such preventive actions were taken resulting in the latest coronavirus emergence detected in late 2019 which quickly spread pandemically. The risk of similar coronavirus outbreaks in the future remains high. In addition to controlling the COVID-19 pandemic, we must undertake vigorous scientific, public health, and societal actions, including significantly increased funding for basic and applied research addressing disease emergence, to prevent this tragic history from repeating itself.

Indexed as

AnimalsBetacoronavirusChiropteraCoronavirus InfectionsCOVID-19HumansPandemicsPneumonia, ViralPublic HealthSARS-CoV-2

Identifiers

PMID32700664
PMCPMC7470595
OpenAlexW3044116551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.