Evidence map›Paper›PMID 32700662›Full record

ArticleThe American journal of tropical medicine and hygiene2020

Major Depression and Stigma among Individuals with Multidrug-Resistant Tuberculosis in South Africa.

Thirusha Naidu, Suntosh R Pillay, Suvira Ramlall, Sbusisiwe Sandra Mthembu, Nesri Padayatchi, Jonathan K Burns, Andrew Tomita

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Adaptation and validation of perceived HIV and TB stigma scales among persons with TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
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  12. Adaptation and validation of a TB stigma scale for adolescents in Lima, Peru.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
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  14. Review
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  20. Bridging the Gap: Navigating the Nexus of Tuberculosis and Mental Well-being.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Thirusha Naidu1Behavioural Medicine, University of KwaZulu-Natal, Durban, South Africa.
Suntosh R Pillay2Department of Psychiatry, University of KwaZulu-Natal, Durban, South Africa.
Suvira Ramlall2Department of Psychiatry, University of KwaZulu-Natal, Durban, South Africa.
Sbusisiwe Sandra Mthembu3South African Medical Research Council, Durban, South Africa.
Nesri Padayatchi4MRC HIV-TB Pathogenesis and Treatment Research Unit, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Jonathan K Burns2Department of Psychiatry, University of KwaZulu-Natal, Durban, South Africa.
Andrew Tomita6Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa.
University of KwaZulu-Natal · ZACentre for the AIDS Programme of Research in South Africa · ZASouth African Medical Research Council · ZAUniversity of Exeter · GB

Funding

Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
6 · The paper itself

Abstract

Stigma is an important social determinant of health-seeking behavior; however, the nature and extent of its association with depression among people living with multidrug-resistant tuberculosis (MDR-TB) are not well-understood. We enrolled 200 microbiologically confirmed MDR-TB inpatients at a TB specialist hospital in KwaZulu-Natal Province, an area considered the epicenter for MDR-TB coinfection in South Africa. Four aspects of stigma and their association with major depression were assessed through individual interviews: 1) community and 2) patient perspectives toward TB, and 3) community and 4) patient perspectives toward HIV. A major depressive episode (MDE), HIV coinfection, and low income were significantly associated with greater stigma subscales. Based on an adjusted regression model, the MDE was the only factor independently associated with (all aspects of) stigma. These results indicate the potential utility of addressing stigma associated with the MDE as an important step in improving health-seeking behavior to promote adherence and retention in care.

Indexed as

HIV InfectionsSocial StigmaAdultExtensively Drug-Resistant TuberculosisFemaleHumansInpatientsMajor Depressive DisorderMaleMiddle AgedPatient ComplianceRetention in CareSouth AfricaTuberculosis, Multidrug-ResistantYoung Adult

Identifiers

PMID32700662
PMCPMC7470525
OpenAlexW3044383269

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.