ReviewJournal of biological rhythms2020
Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review.
Review in Journal of biological rhythms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 127 citations in OpenAlex.
- Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans.Journal of biological rhythms · 2021Trial
- Decoding of Nocturnal Fasting and Health: Possible Role of Zeitgebers and Melatonin.Annals of neurosciences · 2026Review
- Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence.Pharmacology research & perspectives · 2026Review
- Home-Court Advantage and the Associations of Travel and Jet Lag with Team Performance in the Women's National Basketball Association (WNBA).Sports medicine - open · 2026Article
- Machine-learning classification of bipolar disorder incorporating wearable-derived core body temperature and actigraphy-derived sleep indices.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Reward Sensitivity's Associations with Morningness-Eveningness and Other Circadian-Coupled Behavioral Phenomena: A Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Relationships.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- HairTime: A noninvasive assay for estimating circadian phase from a single hair sample.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems.Frontiers in aging neuroscience · 2026Review
- Performance of Blood-Based Biomarkers for Human Circadian Pacemaker Phase: Training Sets Matter As Much As Feature-Selection Methods.Journal of biological rhythms · 2025Article
- The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review.Clocks & sleep · 2025Review
- Dampened circadian amplitude of EEG power in women after menopause.Journal of sleep research · 2025Article
- The relationship between sleep and circadian-sleep phase angles based on dim light melatonin onset predicted from light and activity data.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Circadian clock dysfunction in Parkinson's disease: mechanisms, consequences, and therapeutic strategy.NPJ Parkinson's disease · 2025Review
- Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo.PLoS biology · 2025Article
- Pathophysiological Models of Hypersomnolence Associated With Depression.Biological psychiatry global open science · 2025Review
- Personalization of Cancer Treatment: Exploring the Role of Chronotherapy in Immune Checkpoint Inhibitor Efficacy.Cancers · 2025Review
- Report from the WPA Section on Psychiatry and Sleep-Wakefulness Disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Investigating the impact of sleep quality on cognitive functions among students in Tokyo, Japan, and London, UK.Frontiers in sleep · 2025Article
- The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective.Npj biological timing and sleep · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The temporal organization of molecular and physiological processes is driven by environmental and behavioral cycles as well as by self-sustained molecular circadian oscillators. Quantification of phase, amplitude, period, and disruption of circadian oscillators is essential for understanding their contribution to sleep-wake disorders, social jet lag, interindividual differences in entrainment, and the development of chrono-therapeutics. Traditionally, assessment of the human circadian system, and the output of the SCN in particular, has required collection of long time series of univariate markers such as melatonin or core body temperature. Data were collected in specialized laboratory protocols designed to control for environmental and behavioral influences on rhythmicity. These protocols are time-consuming, expensive, and not practical for assessing circadian status in patients or in participants in epidemiologic studies. Novel approaches for assessment of circadian parameters of the SCN or peripheral oscillators have been developed. They are based on machine learning or mathematical model-informed analyses of features extracted from 1 or a few samples of high-dimensional data, such as transcriptomes, metabolomes, long-term simultaneous recording of activity, light exposure, skin temperature, and heart rate or
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.