ArticleBrain imaging and behavior2021
Cerebral blood flow alterations in hemodialysis patients with and without restless legs syndrome: an arterial spin labeling study.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Global prevalence of restless legs syndrome among hemodialysis patients: A systematic review and meta-analysis.Brain and behavior · 2024Pooled it
- Regional cerebral blood flow in a patient with restless legs syndrome exhibiting pramipexole-induced hypersexuality.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Cognitive Impairment in Chronic Kidney Disease Across Different Stages: The Role of Structural and Perfusion-Driven Functional Connectivity Changes.Brain and behavior · 2025Article
- Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study.BMC neurology · 2024Article
- Restless Legs Syndrome in Hemodialysis Patients: Clinical and Electrophysiological Study.Journal of multidisciplinary healthcare · 2024Article
- Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Neuroanatomy and Functional Connectivity in Patients with Parkinson's Disease with or without Restless Legs Syndrome.Neurology and therapy · 2022Article
- Functional Magnetic Resonance Imaging Studies in Sexual Medicine: A Primer.The journal of sexual medicine · 2022Article
- Long-term hemodialysis may affect enlarged perivascular spaces in maintenance hemodialysis patients: evidence from a pilot MRI study.Quantitative imaging in medicine and surgery · 2022Article
- Altered cerebral blood flow in patients with unilateral venous pulsatile tinnitus: an arterial spin labeling study.The British journal of radiology · 2021Article
- Association between Restless Legs Syndrome and Sleep Disturbance and 3-Year Mortality in Hemodialysis Patients.Kidney diseases (Basel, Switzerland)Article
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
Hemodialysis with restless legs syndrome (HD-RLS) is associated with alterations in neuronal function, the blood-brain barrier and iron deposition, thus affecting cerebral metabolism and perfusion. This study utilized three-dimensional arterial spin labeling (ASL) to identify HD-RLS-related perfusion patterns and potential relationships with disease severity. Twenty-six HD-RLS patients, 30 hemodialysis patients without restless legs syndrome (HD-nRLS) and 30 age-, sex-, and education-matched healthy controls were included in this study. One-way analysis of covariance and post hoc analyses were used to assess differences in cerebral blood flow (CBF) values, demographics and clinical data among the three groups. Pearson's correlation analysis was conducted between altered CBF values in the HD-RLS group and clinical data. Compared with HD-nRLS patients, HD-RLS patients showed increased CBF in the right primary motor cortex (false discovery rate [FDR]-corrected P < 0.05). Compared with the normal controls, both HD subgroups (i.e., those with and without RLS) exhibited consistent CBF changes, including increased CBF in the left medial superior frontal gyrus and bilateral thalamus and decreased CBF in the left insular cortices (FDR-corrected P < 0.05). This abnormal hyperperfusion in the sensorimotor cortex and basal ganglia provides evidence for a sensory processing disorder in RLS that may be involved in the pathogenesis of RLS in HD patients.
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