ReviewMolecular neurobiology2020
Role of Circular Ribonucleic Acids in the Treatment of Traumatic Brain and Spinal Cord Injury.
Review in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- circ_0044235 exacerbates neuroinflammation and apoptosis following spinal cord injury by targeting miR-338-5p.Journal of orthopaedic surgery and research · 2026Article
- NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025Review
- Circ-KATNAL1 Knockdown Reduces Neuronal Apoptosis and Alleviates Spinal Cord Injury Through the miR-98-5p/PRDM5 Regulatory Axis.Molecular biotechnology · 2024Article
- The Role of Exosomes from Mesenchymal Stem Cells in Spinal Cord Injury: A Systematic Review.International journal of stem cells · 2024Review
- Physiological and pathological functions of circular RNAs in the nervous system.Neural regeneration research · 2024Review
- Clinical applications of stem cell-derived exosomes.Signal transduction and targeted therapy · 2024Review
- Exosomes Secreted from circZFHX3-modified Mesenchymal Stem Cells Repaired Spinal Cord Injury Through mir-16-5p/IGF-1 in Mice.Neurochemical research · 2022Article
- DNA Methylation-Related circRNA_0116449 Is Involved in Lipid Peroxidation in Traumatic Brain Injury.Frontiers in molecular neuroscience · 2022Article
- circ_014260/miR-384/THBS1 aggravates spinal cord injury in rats by promoting neuronal apoptosis and endoplasmic reticulum stress.American journal of translational research · 2022Article
- Article
- CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9.Cell cycle (Georgetown, Tex.) · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The causal and pathogenetic factors linked to traumatic brain injury (TBI) and spinal cord injury (SCI) are complex. This complexity is a contributive factor in the minimal improvement outcomes of injured individuals. Several studies have demonstrated the potentiality of stem cells in facilitating neuronal growth and improve outcome in various neurological conditions, including TBI and SCI. However, the efficiency concerning stem cell delivery at injured sites is open to question. Circular ribonucleic acids (circular RNAs) have recently been the focus of attention owing to their disparate functions and features in vivo. Exosomes have close relationship with circular RNAs and might have a significant impact on circular RNA expressions. Herein, we reviewed the specific functions of circular RNAs, exosomes, and stem cells in central nervous system conditions, particularly TBI and SCI, and attempted to show the connection among them. Our analyses showed the role of circular RNAs in brain/spinal cord injuries to be multifaceted, as they can modulate several signaling mechanisms while also acting as sponges for microRNAs and binding to their sites. Additionally, circular RNAs can activate several biological, molecular, and cellular activities in the wake of brain/spinal cord injuries. Thus, both non-pharmacological and pharmacological interventions centered on the regulation of circular RNAs could be promising for TBI and SCI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.