Evidence map›Paper›PMID 32700226›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Optical coherence tomography angiography findings in Huntington's disease.

Laura Giovanna Di Maio, Daniela Montorio, Silvio Peluso, Pasquale Dolce, Elena Salvatore, Giuseppe De Michele, Gilda Cennamo

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Observational
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Huntington's disease and neurovascular structure of retina.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  12. Article
  13. Review
  14. The vessel density of the superficial retinal capillary plexus as a new biomarker in cerebral small vessel disease: an optical coherence tomography angiography study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laura Giovanna Di MaioDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy.
Daniela MontorioDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy. da.montorio@gmail.com.ORCID http://orcid.org/0000-0003-1423-9621
Silvio PelusoDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy.
Pasquale DolceEye Clinic, Public Health Department, University of Naples Federico II, Naples, Italy.
Elena SalvatoreDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy.
Giuseppe De MicheleDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy.
Gilda CennamoEye Clinic, Public Health Department, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the retinal and choriocapillaris vascular networks in macular region and the central choroidal thickness (CCT) in patients affected by Huntington disease (HD), using optical coherence tomography angiography (OCTA) and enhanced depth imaging spectral-domain OCT (EDI SD-OCT).

methodsWe assessed the vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using OCTA, while CCT was measured by EDI SD-OCT.

resultsSixteen HD patients (32 eyes) and thirteen healthy controls (26 eyes) were enrolled in this prospective study. No significant difference in retinal and choriocapillaris VD was found between HD patients and controls while CCT turned to be thinner in patients respect to controls. There were no significant relationships between OCTA findings and neurological parameters.

conclusionThe changes in choroidal structure provide useful information regarding the possible neurovascular involvement in the physiopathology of HD. Choroidal vascular network could be a useful parameter to evaluate the vascular impairment that occurs in this neurodegenerative disease.

Indexed as

Huntington DiseaseNeurodegenerative DiseasesFluorescein AngiographyHumansProspective StudiesRetinal VesselsTomography, Optical CoherenceCentral choroidal thicknessHuntington diseaseOptical coherence tomography angiographyVessel density

Identifiers

PMID32700226
OpenAlexW3045110060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.