Evidence map›Paper›PMID 32700105›Full record

ArticleNeuroradiology2020

Microstructural damage of the cortico-striatal and thalamo-cortical fibers in Fabry disease: a diffusion MRI tractometry study.

Sirio Cocozza, Simona Schiavi, Giuseppe Pontillo, Matteo Battocchio, Eleonora Riccio, Simona Caccavallo, Camilla Russo, Teodolinda Di Risi, Antonio Pisani, Alessandro Daducci and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sirio CocozzaDepartment of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Simona SchiaviDepartment of Computer Science, University of Verona, Verona, Italy.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University "Federico II", Naples, Italy. giuseppe.pon@gmail.com.ORCID http://orcid.org/0000-0001-5425-1890
Matteo BattocchioDepartment of Computer Science, University of Verona, Verona, Italy.
Eleonora RiccioNational Research Council of Italy (IRIB CNR), Institute for Biomedical Research and Innovation, Palermo, Italy.
Simona CaccavalloDepartment of Public Health, Nephrology Unit, University "Federico II", Naples, Italy.
Camilla RussoDepartment of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Teodolinda Di RisiDepartment of Public Health, Nephrology Unit, University "Federico II", Naples, Italy.
Antonio PisaniDepartment of Public Health, Nephrology Unit, University "Federico II", Naples, Italy.
Alessandro DaducciDepartment of Computer Science, University of Verona, Verona, Italy.
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Federico II University Hospital · ITUniversity of Verona · ITInstitute for Biomedical Research and Innovation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent evidences have suggested the possible presence of an involvement of the extrapyramidal system in Fabry disease (FD), a rare X-linked lysosomal storage disorder. We aimed to investigate the microstructural integrity of the main tracts of the cortico-striatal-thalamo-cortical loop in FD patients.

methodsForty-seven FD patients (mean age = 42.3 ± 16.3 years, M/F = 28/21) and 49 healthy controls (mean age = 42.3 ± 13.1 years, M/F = 19/28) were enrolled in this study. Fractional anisotropy (FA), axial (AD), radial (RD), and mean diffusivity (MD) maps were computed for each subject, and connectomes were built using a standard atlas. Diffusion metrics and connectomes were then combined to carry on a diffusion MRI tractometry analysis. The main afferent and efferent pathways of the cortico-striatal-thalamo-cortical loop (namely, bundles connecting the precentral gyrus (PreCG) with the striatum and the thalamus) were evaluated.

resultsWe found the presence of a microstructural involvement of cortico-striatal-thalamo-cortical loop in FD patients, predominantly affecting the left side. In particular, we found significant lower mean FA values of the left cortico-striatal fibers (p = 0.001), coupled to higher MD (p = 0.001) and RD (p < 0.001) values, as well as higher MD (p = 0.01) and RD (p = 0.01) values at the level of the thalamo-cortical fibers.

conclusionWe confirmed the presence of an alteration of the extrapyramidal system in FD patients, in line with recent evidences suggesting the presence of brain changes as a possible reflection of the subtle motor symptoms present in this condition. Our results suggest that, along with functional changes, microstructural damage of this pathway is also present in FD patients.

Indexed as

AdultAnisotropyBrainCase-Control StudiesConnectomeCross-Sectional StudiesDiffusion Tensor ImagingFabry DiseaseFemaleHumansImage Interpretation, Computer-AssistedMaleRetrospective StudiesBrainFabry diseaseMagnetic resonance imagingTractometry

Identifiers

PMID32700105
PMCPMC7568710
OpenAlexW3044388915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.