Evidence map›Paper›PMID 32700040›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020

Antimicrobial effects of craniopharyngioma cystic fluid.

Luxwell Jokonya, Tsungai Reid, Maritha Kasambala, Tariro Lavender Mduluza-Jokonya, Graham Fieggen, Takafira Mduluza, Kazadi K N Kalangu, Thajasvarie Naicker

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Adamantinomatous craniopharyngioma: evolution in the management.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  4. Treatment of Cystic Craniopharyngiomas: An Update.Advances and technical standards in neurosurgery · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Luxwell JokonyaOptics & Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa. doclux@gmail.com.ORCID 0000-0002-5527-0134
Tsungai ReidBiochemistry Department, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.
Maritha KasambalaBiochemistry Department, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.
Tariro Lavender Mduluza-JokonyaOptics & Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
Graham FieggenDepartment of Neurosurgery, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Takafira MduluzaBiochemistry Department, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.
Kazadi K N KalanguDepartment of Surgery, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Avondale, Harare, Zimbabwe.
Thajasvarie NaickerOptics & Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
University of Zimbabwe · ZWUniversity of KwaZulu-Natal · ZAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumours are known to increase the risk of infections, especially those occurring in the central nervous system where insertion of surgical hardware/shunts such as in craniopharyngiomas may be required. However, infections are surprisingly scarce in craniopharyngioma cases. In this study, we explored the possibility of antimicrobial effects of craniopharyngioma cystic fluid.

methodsThe antibacterial effect of craniopharyngioma cystic fluid samples against selected human pathogens: Escherichia. coli, S. aureus and S. pneumoniae were determined using the agar disc diffusion method. Streptomycin and ampicillin were used as controls. The test organisms were cultured in Mueller-Hinton broth overnight at 37 °C. McFarland standard was used as a reference to adjust the inoculum size of each test organism to a concentration of 1 × 10

resultsThe craniopharyngioma cystic fluid inhibited growth of Gram-positive bacteria S. aureus and S. pneumoniae, but not the Gram-negative bacteria, E. coli. The samples showed the highest zones of S. pneumoniae growth inhibition of up to 20.0 ± 1.0 mm compared with 18.0 ± 1.0 mm of streptomycin and 9.0 ± 0.0 mm of ampicillin.

conclusionCraniopharyngioma cystic fluid showed significant antibacterial properties against Gram-positive bacteria. This novel finding has implications in the way we view infections in craniopharyngioma patients. More studies need to be carried out to further elucidate this unique finding and possibly exploit these antimicrobial properties.

Indexed as

Anti-Infective AgentsCraniopharyngiomaPituitary NeoplasmsAnti-Bacterial AgentsEscherichia coliHumansMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsAntibacterialCraniopharyngioma fluid propertiesMachinery oil fluidTumour infection

Identifiers

PMID32700040
OpenAlexW3043880937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.