Evidence map›Paper›PMID 32699972›Full record

ArticleVirologica Sinica2020

Mild Cytokine Elevation, Moderate CD4

Ran Jia, Xiangshi Wang, Pengcheng Liu, Xiaozhen Liang, Yanling Ge, He Tian, Hailing Chang, Hao Zhou, Mei Zeng, Jin Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. T Regulatory Cell Subsets Do Not Restore for One Year After Acute COVID-19.International journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Improving the Efficacy of Regulatory T Cell Therapy.Clinical reviews in allergy & immunology · 2022
    Review
  15. Review
  16. Review
  17. The Dynamic Role of FOXP3Frontiers in immunology · 2022
    Review
  18. Review
  19. Review
  20. Extracellular ATP and Imbalance of CD4+ T Cell Compartment in Pediatric COVID-19.Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ran Jia *Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, 201102, China.
Xiangshi Wang *Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Pengcheng Liu *Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, 201102, China.
Xiaozhen LiangKey Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Yanling GeDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
He TianDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Hailing ChangDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Hao ZhouShanghai Kehua Bio-Engineering Co., Ltd., Shanghai 200233, China.
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Jin XuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, 201102, China. jinxu_125@163.com.ORCID http://orcid.org/0000-0003-2876-2712

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with Coronavirus Disease 2019 (COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn't been reported. Therefore we initiated this study to figure out the features of immune response in children with COVID-19. Sera and whole blood cells from 19 children with COVID-19 during different phases after disease onset were collected. The cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon (IFN)-γ-induced protein 10 (IP10), interleukin (IL)-10 and IL-16. We observed an increase in T helper (Th)-2 cells and a suppression in regulatory T cells (Treg) in patients during acute phase, but no significant response was found in the IFN-γ-producing or tumor necrosis factor (TNF)-α-producing CD8

Indexed as

AdolescentAntibodies, ViralAntibody FormationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChemokinesChildChild, PreschoolCOVID-19CytokinesFemaleHumansImmunity, HumoralImmunoglobulin GInfantInterferon-gammaAntibodies, ViralChemokinesCytokinesIL10 protein, humanImmunoglobulin GInterferon-gammaInterleukin-10Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Antibody dynamicsCOVID-19CytokineSARS-CoV-2T cell immune response

Identifiers

PMID32699972
PMCPMC7373847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.