ArticleCureus2020
Radiographic Trends for Infield Recurrence After Radiosurgery for Cerebral Metastases.
Article in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed, 0 citations in OpenAlex.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Recurrence following stereotactic radiosurgery (SRS) for the treatment of cerebral metastases is not uncommon. Recurrence can represent recurrent tumor and/or radiation necrosis. The radiographic response to Gamma Knife (GK) treatment is variable with some remaining stable, some decreasing in size, some increasing in size, while some may show a combination of all three. For tumors that demonstrate progression on MRI, the question to intervene with additional surgical or radiation therapy and the timing of such intervention remains debatable. In this study, we retrospectively reviewed surveillance MRIs of post-GK cerebral metastases to determine if radiographic trends are a predictor of infield progression. Methods A retrospective review of cerebral metastases treated with GK radiosurgery with at least two consecutive post-GK MRI scans was performed. Infield progression was defined by new enhancement increased by at least 25% in two out of three dimensions on two consecutive scans. Primary endpoints for infield recurrence were either continued observation, therapeutic intervention, or withdrawal of care. Results A total of 579 cerebral metastases were treated with GK radiosurgery. A total of 123 metastases demonstrated radiographic progression on one follow-up MRI scan. Of those, 75% demonstrated continued progression follow-up imaging, while 25% stabilized or regressed. For post-GK metastases demonstrating progression on two consecutive MRI scans, 85% of lesions continued to progress, whereas only 15% demonstrated stabilization or regression. A total of 91% of lesions either require intervention or demonstrate continued progression with observation at this timepoint. Cumulatively 100% of metastases with radiographic progression on ≥3 consecutive MRIs went on to need further intervention. Conclusion Approximately one-fourth of infield recurrence demonstrating progression on the first surveillance MRI will stabilize or regress. Those demonstrating infield progression on two consecutive MRI scans should be considered treatment failures. Early interventions before tumor volume increases in size or patients require high-dose steroids maybe beneficial.
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