Evidence map›Paper›PMID 32699635›Full record

ArticleSAGE open medical case reports2020

Finding of pathological thrombomodulin gene variant in a patient with idiopathic nodular glomerulosclerosis and chronic thrombotic microangiopathy-like changes.

Ramy Hanna, Jonathan E Zuckerman, Antoney Ferrey, Everado Arias Torres, Sam Tonthat, Marina Barsoum, Lena Ghobry, Olivia Wassef, Kamyar Kalantarzadeh

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ramy HannaDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.ORCID https://orcid.org/0000-0003-1807-8909
Jonathan E ZuckermanDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Antoney FerreyDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Everado Arias TorresDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Sam TonthatDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
Marina BarsoumSchool of Pharmaceutical Sciences, Chapman University, Orange, CA, USA.
Lena GhobryUniversity of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Olivia WassefDivision of Nephrology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kamyar KalantarzadehDivision of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Irvine, CA, USA.
University of California, Irvine · USUniversity of California, Los Angeles · USChapman University · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic nodular glomerulosclerosis is an unusual histopathological finding that has commonly been observed in male smokers with hypertension. It has remained an enigmatic condition and is best described as a diabetic pattern of glomerular injury seen in non-diabetic patients. It is also one of the few nicotine (smoking)-associated/smoking-associated patterns of renal injury. We present an even more unusual manifestation of this pathological finding in a 59-year-old Hispanic female who presented with chronic kidney disease approaching need for renal replacement therapy. The patient had idiopathic nodular glomerulosclerosis on kidney biopsy, despite no prior history of diabetes, nor smoking history, including no secondhand smoking exposure. The patient did have hypertension. The renal biopsy also showed evidence of chronic thrombotic-microangiopathic changes within arteries and arterioles. Genetic testing of the alternative pathway revealed an unusual and likely pathological variant of thrombomodulin supporting complement dysfunction as having a role in the presentation.

Indexed as

alternative pathway activationhypertensionIdiopathic nodular sclerosisthrombomodulin mutationthrombotic microangiopathy

Identifiers

PMID32699635
PMCPMC7357015
OpenAlexW3041818278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.