ArticleClinical kidney journal2020
The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design.
Article in Clinical kidney journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Prenatal body fluid analysis in the evaluation of CAKUT.Pediatric nephrology (Berlin, Germany) · 2026Review
- Fetal Urinary Cystatin C, NGAL and Beta-2-Microglobulin as Predictors of Postnatal Renal Function Impairment and Death in Fetuses with Lower Urinary Tract Obstruction.Journal of clinical medicine · 2026Article
- Advancing the state of the art in congenital obstructive uropathy.Nature reviews. Urology · 2025Article
- Evaluation of predictive performance of fetal urinary inflammatory markers of postnatal kidney function in fetuses with posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2025Article
- Use of prenatal ultrasound findings to predict postnatal outcome in fetuses with lower urinary tract obstruction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2024Article
- Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.Journal of the American Society of Nephrology : JASN · 2024Article
- Artificial Intelligence Tools in Pediatric Urology: A Comprehensive Review of Recent Advances.Diagnostics (Basel, Switzerland) · 2024Review
- Antenatal Determinants of Postnatal Renal Function in Fetal Megacystis: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Congenital anomalies of the kidney and urinary tract: antenatal diagnosis, management and counselling of families.Pediatric nephrology (Berlin, Germany) · 2024Article
- Comparison of clean catch and bag urine using LC-MS/MS proteomics in infants.Pediatric nephrology (Berlin, Germany) · 2024Article
- Chronic Kidney Disease in Boys with Posterior Urethral Valves-Pathogenesis, Prognosis and Management.Biomedicines · 2022Review
- Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.Nature reviews. Urology · 2022Review
- Postnatal Management in Congenital Lower Urinary Tract Obstruction With and Without Prenatal Vesicoamniotic Shunt.Frontiers in pediatrics · 2021Article
- Comparison of the amniotic fluid and fetal urine peptidome for biomarker discovery in renal developmental disease.Scientific reports · 2020Article
- A single-center study to evaluate the efficacy of a fetal urine peptide signature predicting postnatal renal outcome in fetuses with posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Review
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Authors and funding
22 authors at 13 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted
methodsParticipants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature.
resultsIn this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment.
conclusionsAccurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.
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