Evidence map›Paper›PMID 32699545›Full record

ArticleInternational journal of pediatric endocrinology2020

A synchronous papillary and follicular thyroid carcinoma presenting as a large toxic nodule in a female adolescent.

Joke Van Vlaenderen, Karl Logghe, Eva Schiettecatte, Hubert Vermeersch, Wouter Huvenne, Kathleen De Waele, Hanne Van Beveren, Jo Van Dorpe, David Creytens, Jean De Schepper

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pediatric endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Thyroid Collision Tumor Comprising of Papillary and Follicular Carcinoma: A Diagnostic and Therapeutic Conundrum.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  3. Article
  4. Synchronous Papillary and Follicular Carcinoma with Scalp and Nodal Metastasis: A case report with review of literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  5. Article
  6. Synchronous Metastatic Follicular Carcinoma andIndian journal of surgical oncology · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Joke Van VlaenderenDepartment of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.ORCID 0000-0002-0920-3774
Karl LoggheDepartment of Pediatrics, AZ Delta, Roeselare, Brugsesteenweg 90, 8800 Roeselare, Belgium.
Eva SchiettecatteDepartment of Radiology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Hubert VermeerschDepartment of Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Wouter HuvenneDepartment of Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Kathleen De WaeleDepartment of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Hanne Van BeverenDepartment of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Jo Van DorpeDepartment of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
David CreytensDepartment of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Jean De SchepperDepartment of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Ghent University Hospital · BEAZ Delta · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

case presentationWe report for the first time a synchronous papillary and follicular thyroid carcinoma in a 12-year-old girl presenting with a large (5 cm diameter) left thyroid nodule, an increased left and right upper pole technetium tracer uptake at scintigraphy and hyperthyroidism. The uptake at the right lobe was explained by the crossing of the left nodule to the right site of the neck at Computed Tomography (CT) scanning.

backgroundAlthough thyroid nodules are less common in children than in adults, there is more vigilance required in children because of the higher risk of malignancy. According to literature, about 5% of the thyroid nodules in adults are malignant versus 20-26% in children. The characteristics of 9 other pediatric cases with a differentiated thyroid carcinoma presenting with a toxic nodule, which have been reported during the last 20 years, are summarized. A nodular size of more than 3.5 cm and female predominance was a common finding.

conclusionsThe presence of hyperthyroidism in association with a hyperfunctioning thyroid nodule does not rule out thyroid cancer and warrants careful evaluation, even in the absence of cervical lymph node invasion.

Indexed as

ChildrenFollicular thyroid carcinomaHyperthyroidismPapillary thyroid carcinomaPediatricToxic nodule

Identifiers

PMID32699545
PMCPMC7372872
OpenAlexW3042611162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.