Evidence map›Paper›PMID 32699505›Full record

ReviewDialogues in clinical neuroscience2020

Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology
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Emily R Perkins, Keanan J Joyner, Christopher J Patrick, Bruce D Bartholow, Robert D Latzman, Colin G DeYoung, Roman Kotov, Ulrich Reininghaus, Samuel E Cooper, Mohammad H Afzali and 13 more

Abstract readReview
In one paragraph

Review in Dialogues in clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Individual-Specific Animated Profiles of Mental Health.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
    Article
  6. Article
  7. Article
  8. Variants of the P3 event-related potential operate as indicators of distinct mechanisms contributing to problematic alcohol use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. A Hierarchical Taxonomy of Psychopathology (HiTOP) Primer for Mental Health Researchers.Clinical psychological science : a journal of the Association for Psychological Science · 2022
    Article
  17. Article
  18. Article
  19. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Emily R PerkinsDepartment of Psychology, Florida State University, Tallahassee, Florida, US. Authors contributed equally to manuscript.
Keanan J JoynerDepartment of Psychology, Florida State University, Tallahassee, Florida, US. Authors contributed equally to manuscript.
Christopher J PatrickDepartment of Psychology, Florida State University, Tallahassee, Florida, US.
Bruce D BartholowDepartment of Psychological Sciences, University of Missouri, Columbia, Missouri, US.
Robert D LatzmanDepartment of Psychology, Georgia State University, Atlanta, Georgia, US.
Colin G DeYoungDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, US.
Roman KotovDepartment of Psychiatry, Stony Brook University, Stony Brook, New York, US.
Ulrich ReininghausDepartment of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Samuel E CooperDepartment of Psychiatry, University of Texas at Austin, Texas, US.
Mohammad H AfzaliDepartment of Psychiatry, University of Montreal, Quebec, Canada.
Anna R DochertyDDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, US.
Michael N DretschUS Army Medical Research Directorate - West, Walter Reed Army Institute for Research, Joint Base Lewis-McCord, Washington, US.
Nicholas R EatonDepartment of Psychology, Stony Brook University, Stony Brook, New York, US.
Vina M GoghariDepartment of Psychology and Graduate Department of Psychological Clinical Science, University of Toronto, Ontario, Canada.
John D HaltiganDDepartment of Psychiatry, University of Toronto, and Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Robert F KruegerDDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, US.
Elizabeth A MartinDDepartment of Psychological Science, University of California, Irvine, California, US.
Giorgia MicheliniDepartment of Psychiatry, Stony Brook University, Stony Brook, New York, US.
Anthony C RuoccoDepartment of Psychology and Graduate Department of Psychological Clinical Science, University of Toronto, Ontario, Canada.
Jennifer L TackettDepartment of Psychology, Northwestern University, Evanston, Illinois, US.
Noah C VenablesDMinneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota, US.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, Georgia, US.
David H ZaldDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, US .

Funding

Integrated Clinical Neuroscience Training for Translational ResearchT32MH093311 · NIMH · FLORIDA STATE UNIVERSITY · PI LISA A ECKEL, Pamela K. Keel · 2012 to 2026
$2.3M
Modeling Dimensionality and Genetic Heterogeneity in SchizophreniaK01MH109765 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI DOCHERTY, ANNA R. · 2016 to 2019
$675k
Callousness and Distress Processing: An ERP Investigation of Attention and Emotion in Adolescence.F31MH122096 · NIMH · FLORIDA STATE UNIVERSITY · PI PERKINS, EMILY REED · 2019 to 2020
$74k
NIMH NIH HHS F31 MH122096NIMH NIH HHS K01 MH109765NIMH NIH HHS T32 MH093311
6 · The paper itself

Abstract

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures than traditional categorical diagnoses given its enhanced reliability. However, one complication is that observed biological correlates of clinical symptoms can reflect various factors, ranging from dispositional risk to consequences of psychopathology. In this paper, we argue that the HiTOP model provides an optimized framework for conducting research on the biological correlates of psychopathology from an ontogenetic perspective that distinguishes among indicators of liability, current symptoms, and consequences of illness. Through this approach, neurobiological research can contribute more effectively to identifying individuals at high dispositional risk, indexing treatment-related gains, and monitoring the consequences of mental illness, consistent with the aims of the HiTOP framework.
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Indexed as

ClassificationCross-Sectional StudiesHumansMental DisordersNeurobiologyProspective StudiesPsychopathologyReproducibility of ResultsdimensionalHierarchical Taxonomy of PsychopathologyliabilityneurobiologyontogeneticpsychopathologyRDoC

Identifiers

PMID32699505
PMCPMC7365294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.