ReviewDialogues in clinical neuroscience2020
Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .
Review in Dialogues in clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern.Alpha psychiatry · 2024Article
- Catatonia.Nature reviews. Disease primers · 2024Review
- Bipolar disorders and schizophrenia: discrete disorders?Frontiers in psychiatry · 2024Review
- Early-onset catatonia associated withFrontiers in psychiatry · 2023Article
- Functional Neurologic Disorders, disorders to be managed by neurologists, or are neurologists wandering in a dangerous field with inadequate resources?Frontiers in psychiatry · 2023Review
- Potential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial - CADOT.Frontiers in psychiatry · 2023Article
- A neuropsychological study on Leonhard's nosological system.European archives of psychiatry and clinical neuroscience · 2022Article
- Catatonia Psychopathology and Phenomenology in a Large Dataset.Frontiers in psychiatry · 2022Article
- All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders.Molecular psychiatry · 2021Review
- Does a Lack of Awareness of Cycloid Psychosis Hamper Adequate Treatment for Patients Suffering From This Disorder? A Case Report.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion. .
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