Evidence map›Paper›PMID 32699491›Full record

ArticleInformation processing in medical imaging : proceedings of the ... conference2019

Variational Autoencoder with Truncated Mixture of Gaussians for Functional Connectivity Analysis.

Qingyu Zhao, Nicolas Honnorat, Ehsan Adeli, Kilian M Pohl

Abstract read
In one paragraph

Article in Information processing in medical imaging : proceedings of the ... conference, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. SpaRG: Sparsely Reconstructed Graphs for Generalizable fMRI Analysis.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025
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  6. Spatio-Temporal Graph Convolution for Resting-State fMRI Analysis.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020
    Article
  7. Variational AutoEncoder For Regression: Application to Brain Aging Analysis.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qingyu ZhaoStanford University.
Nicolas HonnoratSRI International.
Ehsan AdeliStanford University.
Kilian M PohlSRI International.

Funding

Neuroimaging of Alcohol-Induced Neuroadaptation: Translation From Animals to HumansU01AA013521 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 2001 to 2021
$15.2M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
NCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2M
Cerebellar Structure and Function in AlcoholismR37AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2010 to 2019
$5.4M
Translational Studies of Brain Circuitry Disrupted by AlcoholismK05AA017168 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2008 to 2017
$2.2M
NIAAA NIH HHS K05 AA017168NIAAA NIH HHS R01 AA005965NIAAA NIH HHS R37 AA010723NIAAA NIH HHS U01 AA013521NIAAA NIH HHS U24 AA021697
6 · The paper itself

Abstract

Resting-state functional connectivity states are often identified as clusters of dynamic connectivity patterns. However, existing clustering approaches do not distinguish major states from rarely occurring minor states and hence are sensitive to noise. To address this issue, we propose to model major states using a non-linear generative process guided by a Gaussian-mixture distribution in a low-dimensional latent space, while separately modeling the connectivity patterns of minor states by a non-informative uniform distribution. We embed this truncated Gaussian-Mixture model in a Variational Autoencoder framework to obtain a general joint clustering and outlier detection approach, tGM-VAE. When applied to synthetic data with known ground-truth, tGM-VAE is more accurate in clustering connectivity patterns than existing approaches. On the rs-fMRI of 593 healthy adolescents, tGM-VAE identifies meaningful major connectivity states. The dwell time of these states significantly correlates with age.

Identifiers

PMID32699491
PMCPMC7375028

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.