ArticleNature2020
Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Histone and Histone Acetylation-Related Alterations of Gene Expression in Uninvolved Psoriatic Skin and Their Effects on Cell Proliferation, Differentiation, and Immune Responses.International journal of molecular sciences · 2023Pooled it
- KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems.Scientific reports · 2021Trial
- MNS induces antiviral protection and suppresses inflammation.Annals of medicine · 2026Article
- Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.Nature neuroscience · 2026Article
- HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging.Research square · 2026Article
- Histone modification cross-talk: analytical tools and molecular mechanisms.The Biochemical journal · 2026Review
- ASF1B promotes erythropoiesis by regulating the establishment and enrichment of H3.3 nucleosomes.Nucleic acids research · 2026Article
- Unraveling the complexity of the histone code: implications for gene regulation and disease.Genome biology · 2026Review
- Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity.bioRxiv : the preprint server for biology · 2026Article
- Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11's role in cooperative recognition of diverse targets.Nucleic acids research · 2026Article
- Epigenetic regulation in cancer chemoresistance and combined therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
- Photoperiod-driven gene regulation in the brain ofFrontiers in endocrinology · 2026Article
- Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancyTheranostics · 2026Article
- Comparative genomic analysis reveals the genetic basis of the environmental adaptability of Propylea japonica.BMC genomics · 2025Article
- HIRA defines early replication initiation zones independently of their genome compartment.Nature communications · 2025Article
- Emerging role of SETD2 in the development and function of immune cells.Genes & diseases · 2025Review
- Cytochrome b5 reductase orchestrates IL-1β production in macrophages through FAD.Cell death & disease · 2025Article
- ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis.Nature communications · 2025Article
- A needed nomenclature for nucleosomes.Molecular cell · 2025Review
- Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication.bioRxiv : the preprint server for biology · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 9 institutions in 3 countries.
Anja Armache *Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Shuang Yang *MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Alexia Martínez de PazLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0808-1389
Lexi E RobbinsLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Ceyda DurmazLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Jin Q CheongLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Arjun RavishankarLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-8366-4838
Andrew W DamanLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Dughan J AhimovicLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Thaís KlevornLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2765-1626
Yuan YueMOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Tanja ArslanAdolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.
Shu LinEpigenetics Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Tanya PanchenkoLaboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.
Joel HritCenter for Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Miao WangSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Samuel ThudiumDepartment of Genetics, Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6670-3970
Benjamin A GarciaAdolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.
Erica KorbDepartment of Genetics, Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Karim-Jean ArmacheSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Scott B RothbartCenter for Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0003-1631-5392
Sandra B HakeAdolf-Butenandt Institute, Ludwig-Maximilians University, Munich, Germany.
C David AllisLaboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7589-713X
Haitao LiMOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. lht@tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-6741-293X
Steven Z JosefowiczLaboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. szj2001@med.cornell.edu.ORCID http://orcid.org/0000-0001-7453-779X
Cornell University · USCenter for Life Sciences · CNUniversity of Pennsylvania · USLudwig-Maximilians-Universität München · DENew York University · USVan Andel Institute · USJustus-Liebig-Universität Gießen · DENYU Langone Health · USRockefeller University · US
Funding
Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6MINFLUENCE OF HISTONE H1 AND HMGS ON GENE EXPRESSIONR01GM040922 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ALLIS, CHARLES DAVID · 1989 to 2022
$10.0MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MHistone Variant H3.3 as a Transcription Rheostat in the Immune SystemR01AI148416 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Steven Zvi Josefowicz · 2020 to 2026
$4.6MStructural and functional analysis of gene silencingR01GM115882 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARMACHE, KARIM JEAN · 2015 to 2023
$3.4MMolecular mechanisms of chromatin and epigenetic regulationR35GM124736 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI ROTHBART, SCOTT · 2017 to 2021
$2.4MRegulation of Chromatin by Histone PhosphorylationR00GM113019 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOSEFOWICZ, STEVEN ZVI · 2017 to 2019
$747kImmunology and Microbial Pathogenesis Research Training ProgramT32AI134632 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE, LI, MING · 2019 to 2023
$747kRegulation of Chromatin by Histone PhosphorylationK99GM113019 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOSEFOWICZ, STEVEN ZVI · 2015 to 2016
$180kNCI NIH HHS P01 CA196539NIAID NIH HHS R01 AI118891NIAID NIH HHS R01 AI148416NIAID NIH HHS T32 AI134632NIGMS NIH HHS K99 GM113019NIGMS NIH HHS R00 GM113019NIGMS NIH HHS R01 GM040922NIGMS NIH HHS R01 GM115882NIGMS NIH HHS R35 GM124736
Abstract
Complex organisms can rapidly induce select genes in response to diverse environmental cues. This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing of pathogens by macrophages engages conserved signalling pathways and transcription factors to coordinate the induction of inflammatory genes
Indexed as
Transcription, GeneticAnimalsCell Cycle ProteinsCells, CulturedCo-Repressor ProteinsDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesHumansI-kappa B KinaseMacrophagesMaleMethylationMiceModels, MolecularPhosphorylationCell Cycle ProteinsCo-Repressor ProteinsDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesI-kappa B KinaseSETD2 protein, humanZmynd11 protein, mouse
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.