ArticleCellular & molecular immunology2020
Periarteriolar stroma cells guide T cells from the red to the white pulp in the spleen.
Article in Cellular & molecular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 citing papers in PubMed, 10 citations in OpenAlex.
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- Type I Interferon Signaling on Antigen-Presenting Cells Blunts Cell-Mediated Immunity toward Listeria monocytogenes.Infection and immunity · 2023Article
- Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4.The Journal of clinical investigation · 2022Article
- Lymph node fibroblastic reticular cells steer immune responses.Trends in immunology · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
While both the spleen and lymph nodes are called secondary lymphoid tissues, how lymphocytes enter these tissues are quite different from each other. This is because the architecture of the two types of organs and the mode of lymphocyte migration into these organs are quite distinct. In the spleen, T cells are passively released in the blood flow from the arterioles in the red pulp and marginal zone area. In contrast, T cells in the blood are actively captured on high endothelial venules in lymph nodes by the coordinated actions of CCR7 and several adhesion molecules. A recent finding indicates that T cells, released in the red pulp and marginal zone areas, actively find their way to the white zone by utilizing the migration track created by periarteriolar stromal cells. This finding adds one more piece to our understanding of lymphocyte migration for effective adaptive immune responses in the spleen.
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