ArticleScientific reports2020
DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.Clinical epigenetics · 2023Pooled it
- Epigenetic legacy of early-life undernutrition: methodological lessons from Dutch and Chinese famine studies.Frontiers in genetics · 2026Review
- Association of exposure to famine early in life with indicators of obesity in adulthood: testosterone as a potential mediator?International journal of obesity (2005) · 2025Article
- Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Nutritional Influences on Adiposity Rebound and Cardiometabolic Outcomes in a Prospective Birth Cohort of Low-Birth-Weight Children: A Study Protocol.Wellcome open research · 2025Article
- Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China.BMC women's health · 2023Article
- Maternal Periconceptional Folic Acid Supplementation and DNA Methylation Patterns in Adolescent Offspring.The Journal of nutrition · 2023Article
- Epigenetics in Precision Nutrition.Journal of personalized medicine · 2022Review
- Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk.International journal of environmental research and public health · 2021Review
- Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations.Frontiers in nutrition · 2021Article
- Prenatal famine exposure and adult health outcomes: an epigenetic link.Environmental epigenetics · 2021Review
- The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field.Frontiers in nutrition · 2021Review
- Article
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8 authors.
Funding
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Abstract
The aims of this study were to explore whether DNA methylation at INSR and IGF2 mediated the association of prenatal exposure to the Chinese great famine with adulthood waist circumference (WC) and BMI. A total of 235 subjects were selected into the present study from severely affected province and a neighbor province with less severely affected famine in China through multi-stage clustered random sampling. DNA methylation at the INSR and IGF2 gene promoter regions was detected by the Sequenom's MassARRAY system. The "mediation" package of R was used to evaluate the mediation effect of DNA methylation on the association between prenatal exposure to the famine and adult WC and BMI. The results showed that prenatal famine exposure was significantly associated with higher overall methylation level of the INSR gene (d = 3.6%; 95% CI 1.2-6.0; P = 0.027) and larger adulthood WC (d = 2.72 cm; 95% CI 0.20-5.24; P = 0.034). Furthermore, famine significantly increased methylation levels at four CpG sites. Methylation of the CpG7 site mediated 32.0% (95% CI 5.0-100.0%, P = 0.029) of the association between prenatal exposure to the Chinese great famine and adulthood WC. In conclusion, Epigenetic changes to the INSR might mediate the adverse effect of prenatal famine exposure on WC in adulthood.
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