ArticleNature communications2020
B cell zone reticular cell microenvironments shape CXCL13 gradient formation.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
54 citing papers in PubMed, 83 citations in OpenAlex.
- Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.bioRxiv : the preprint server for biology · 2026Article
- CCL19bioRxiv : the preprint server for biology · 2026Article
- Chronic Kidney Disease-Associated Defect in Humoral Immune Response Is Driven by Inflammation.Toxins · 2026Article
- Review
- A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes.The Journal of experimental medicine · 2026Article
- Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.Research square · 2026Article
- Non-immune regulation of tertiary lymphoid structures in cancer.Frontiers in immunology · 2026Review
- CXCL13 and IL-33 as Immunomodulatory Adjuvants Combined with Respiratory Syncytial Virus Fusion (RSV F) Protein to Enhance Mucosal RSV Vaccination.Infection and drug resistance · 2026Review
- Molecular tools for decoding multicellular systems: from mechanisms to medicine.National science review · 2025Review
- Aggresomes protect mRNA under stress in Escherichia coli.Nature microbiology · 2025Article
- CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling.Journal of neuroinflammation · 2025Article
- Identification of CXCL13 as a Promising Biomarker for Immune Checkpoint Blockade Therapy and PARP Inhibitor Therapy in Ovarian Cancer.Molecular biotechnology · 2025Article
- The Impact of Mast Cells on the Anatomy, Cellular Communication, and Molecular Immune Network of Lymph Nodes.Clinical reviews in allergy & immunology · 2025Review
- Single-cell transcriptomics unveils leukocyte heterogeneity in the gills ofFrontiers in immunology · 2025Article
- Article
- iPAR: a new reporter for eukaryotic cytoplasmic protein aggregation.BMC methods · 2025Article
- HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma.Blood advances · 2024Article
- CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency.Genes & diseases · 2024Article
- Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy-Lysosome Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation.Pharmaceutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 10 institutions in 5 countries.
Jason Cosgrove *York Computational Immunology Lab, University of York, York, UK.
Mario Novkovic *Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.ORCID http://orcid.org/0000-0001-7654-5777
Stefan Albrecht *Theodor Kocher Institute, University of Bern, Bern, Switzerland.
Natalia B PikorInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Zhaoukun ZhouDepartment of Biology, University of York, York, UK.
Lucas OnderInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Urs MörbeInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Jovana CupovicInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Helen MillerDepartment of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0001-7076-4151
Kieran AldenYork Computational Immunology Lab, University of York, York, UK.
Anne ThueryCentre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
Peter O'TooleDepartment of Biology, University of York, York, UK.
Rita PinterKennedy Institute of Rheumatology at the University of Oxford, Oxford, UK.
Simon JarrettKennedy Institute of Rheumatology at the University of Oxford, Oxford, UK.
Emily TaylorCentre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
Daniel VenetzInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Manfred HellerDepartment of Clinical Research, University of Bern, Bern, Switzerland.
Mariagrazia UguccioniInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Daniel F LeglerBiotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.ORCID http://orcid.org/0000-0001-8610-4764
Charles J LaceyYork Computational Immunology Lab, University of York, York, UK.ORCID http://orcid.org/0000-0001-9250-2638
Andrew CoatesworthYork Teaching Hospital NHS Foundation Trust, York, UK.
Wojciech G PolakDepartment of Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.
Tom CupedoDepartment of Hematology, Erasmus University Medical Centre, Rotterdam, Netherlands.
Bénedicte ManouryInstitut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, 149 rue de Sèvres 75015 Paris, France Université René Descartes, 75005, Paris, France.
Marcus ThelenInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Jens V SteinDepartment of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-8199-9586
Marlene WolfTheodor Kocher Institute, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-7283-4683
Mark C LeakeDepartment of Biology, University of York, York, UK. mark.leake@york.ac.uk.ORCID http://orcid.org/0000-0002-1715-1249
Jon TimmisYork Computational Immunology Lab, University of York, York, UK. jon.timmis@sunderland.ac.uk.
Burkhard LudewigInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland. burkhard.ludewig@kssg.ch.ORCID http://orcid.org/0000-0002-7685-573X
Mark C ColesYork Computational Immunology Lab, University of York, York, UK. mark.coles@kennedy.ox.ac.uk.
University of York · GBKantonsspital St. Gallen · CHUniversità della Svizzera italiana · CHUniversity of Bern · CHUniversity of Oxford · GBErasmus University Rotterdam · NLBiotechnology Institute Thurgau · CHDélégation Paris 5 · FRUniversity of Fribourg · CHYork Teaching Hospital NHS Foundation Trust · GB
Funding
Biotechnology and Biological Sciences Research Council BB/F004729/1Biotechnology and Biological Sciences Research Council BB/N006453/1Biotechnology and Biological Sciences Research Council BB/R001235/1Medical Research Council G0601156Medical Research Council MC_PC_15073Medical Research Council MR/K01580X/1Medical Research Council MR/K021125/1Wellcome TrustWellcome Trust 204829Wellcome Trust WT0905024MA
Abstract
Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients. Specifically, CXCL13
Indexed as
Adaptive ImmunityAnimalsB-LymphocytesCathepsin BCell LineCellular MicroenvironmentChemokine CXCL13Computer SimulationDendritic Cells, FollicularExtracellular MatrixHumansMiceMice, KnockoutMicroscopy, FluorescenceModels, BiologicalPalatine TonsilCathepsin BChemokine CXCL13CTSB protein, humanCtsb protein, mouseCXCL13 protein, humanCxcl13 protein, mouseRecombinant Proteins
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.