Evidence map›Paper›PMID 32699239›Full record

SynthesisTranslational psychiatry2020

Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos.

Xueqiu Jian, Tamar Sofer, Wassim Tarraf, Jan Bressler, Jessica D Faul, Wei Zhao, Scott M Ratliff, Melissa Lamar, Lenore J Launer, Cathy C Laurie and 10 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 1 country.

Xueqiu JianBrown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0313-6494
Tamar SoferBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8520-8860
Wassim TarrafInstitute of Gerontology and Department of Health Care Sciences, Wayne State University, Detroit, MI, USA.
Jan BresslerDepartment of Epidemiology, Human Genetics and Environmental Sciences and Human Genetics Center, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
Scott M RatliffDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Melissa LamarDepartment of Behavioral Sciences, Rush Medical College, Chicago, IL, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
Neil SchneidermanDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1661-2402
Clinton B WrightDivision of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Kristine YaffeDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Donglin ZengDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Charles DeCarliDepartment of Neurology, School of Medicine and Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California, Davis, Sacramento, CA, USA.
Thomas H MosleyMemory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. Myriam.Fornage@uth.tmc.edu.ORCID http://orcid.org/0000-0003-0677-8158
University of Michigan · USBrigham and Women's Hospital · USBrown Foundation · USNational Institute of Neurological Disorders and Stroke · USNational Institute on Aging · USRush University Medical Center · USThe University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Davis · USUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USWayne State University · US

Funding

Study of Latinos Investigation of Neurocognitive Aging 2R56AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2020 to 2021
$8.7M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS R01 AG048642NIA NIH HHS U01 AG052409
6 · The paper itself

Abstract

Cognitive function such as reasoning, attention, memory, and language is strongly correlated with brain aging. Compared to non-Hispanic whites, Hispanics/Latinos have a higher risk of cognitive impairment and dementia. The genetic determinants of cognitive function have not been widely explored in this diverse and admixed population. We conducted a genome-wide association analysis of cognitive function in up to 7600 middle aged and older Hispanics/Latinos (mean = 55 years) from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL). Four cognitive measures were examined: the Brief Spanish English Verbal Learning Test (B-SEVLT), the Word Fluency Test (WFT), the Digit Symbol Substitution Test (DSST), the Six-Item Screener (SIS). Four novel loci were identified: one for B-SEVLT at 4p14, two for WFT at 3p14.1 and 6p21.32, and one for DSST at 10p13. These loci implicate genes highly expressed in brain and previously connected to neurological diseases (UBE2K, FRMD4B, the HLA gene complex). By applying tissue-specific gene expression prediction models to our genotype data, additional genes highly expressed in brain showed suggestive associations with cognitive measures possibly indicating novel biological mechanisms, including IFT122 in the hippocampus for SIS, SNX31 in the basal ganglia for B-SEVLT, RPS6KB2 in the frontal cortex for WFT, and CSPG5 in the hypothalamus for DSST. These findings provide new information about the genetic determinants of cognitive function in this unique population. In addition, we derived a measure of general cognitive function based on these cognitive tests and generated genome-wide association summary results, providing a resource to the research community for comparison, replication, and meta-analysis in future genetic studies in Hispanics/Latinos.

Indexed as

Genome-Wide Association StudyPublic HealthAgedCognitionHispanic or LatinoHumansMiddle AgedNeuropsychological TestsUbiquitin-Conjugating EnzymesUBE2K protein, humanUbiquitin-Conjugating Enzymes

Identifiers

PMID32699239
PMCPMC7376098
OpenAlexW3044740254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.