Evidence map›Paper›PMID 32699202›Full record

ArticleJournal of microbiology and biotechnology2020

Galectin-9 Induced by Dietary Prebiotics Regulates Immunomodulation to Reduce Atopic Dermatitis Symptoms in 1-Chloro-2,4-Dinitrobenzene (DNCB)-Treated NC/Nga Mice.

Jeong A Kim, Sung Hak Kim, In Sung Kim, Da Yoon Yu, Gwang Il Kim, Yang Soo Moon, Sung Chan Kim, Seung Ho Lee, Sang Suk Lee, Cheol Heui Yun and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Allergy, asthma & immunology research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jeong A KimDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Sung Hak KimDepartment of Animal Science, Chonnam National University, Gwangju 61186, Republic of Korea 3 Department of Animal Science & Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
In Sung KimDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Da Yoon YuDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Gwang Il KimDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Yang Soo MoonDepartment of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Sung Chan KimDepartment of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Seung Ho LeeDepartment of Nano-Bioengineering, Incheon National University, Incheon 22012, Korea.
Sang Suk LeeDepartment of Animal Science and Technology, Sunchon National University, Sunchon 57922, Republic of Korea.
Cheol Heui YunDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
In Soon ChoiDepartment of Life Science, Silla University, Busan 46958, Republic of Korea.
Kwang Keun ChoDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea.
Gyeongnam National University of Science and Technology · KRHallym University · KRIncheon National University · KRSeoul National University · KRSilla University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a skin disorder that causes chronic itch. We investigated the inhibitory effects of a mixture of prebiotic short-chain galacto-oligosaccharides and long-chain fructooligosaccharides (scGOS/lcFOS), inulin, or β-glucan on AD development in 1-chloro-2,4- dinitrobenzene (DNCB)-treated NC/Nga mice. Mice were randomly assigned to six groups: untreated mice, AD control, positive control (DNCB-treated NC/Nga mice fed a dietary supplement of Zyrtec), and DNCB-treated NC/Nga mice fed a dietary supplement of prebiotics such as scGOS/lcFOS (T1), inulin (T2), or β-glucan (T3). The prebiotic treatment groups (T1, T2, and T3) showed suppression of AD symptoms, Th2 cell differentiation, and AD-like skin lesions induced by DNCB. In addition, prebiotic treatment also reduced the number of microorganisms such as

Indexed as

ImmunomodulationAnimalsBacteriaDermatitis, AtopicDietary SupplementsDinitrochlorobenzeneDisease Models, AnimalGalectinsGastrointestinal MicrobiomeHT29 CellsHumansLymph NodesMaleMesenteryMicePrebioticsDinitrochlorobenzenegalectin 9, mouseGalectinsPrebioticsTlr9 protein, mouseToll-Like Receptor 9Gut microbiotaimmunomodulationprebioticsTh1 cellsTh2 cellsTreg cells

Identifiers

PMID32699202
PMCPMC9745654
OpenAlexW3045174356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.