Evidence map›Paper›PMID 32699114›Full record

ArticleBMJ open diabetes research & care2020

Cost analysis of the flash monitoring system (FreeStyle Libre 2) in adults with type 1 diabetes mellitus.

Itziar Oyagüez, Juan Francisco Merino-Torres, Miguel Brito, Virginia Bellido, Roque Cardona-Hernandez, Fernando Gomez-Peralta, Francisco Morales-Perez

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

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  13. Review
  14. Cost Analysis of FreeStyle LibreDiabetes therapy : research, treatment and education of diabetes and related disorders · 2021
    Article
  15. Glycemic Status Assessment by the Latest Glucose Monitoring Technologies.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Itziar OyagüezPharmacoeconomics & Outcomes Research Iberia, Pozuelo de Alarcon, Madrid, Spain ioyaguez@porib.com.ORCID 0000-0002-3047-6152
Juan Francisco Merino-TorresDepartment of Medicine, Universitat de València Facultat de Medicina i Odontologia, Valencia, Comunitat Valenciana, Spain.ORCID 0000-0002-0191-4504
Miguel BritoEndocrinology and Nutrition, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain.
Virginia BellidoEndocrinology and Nutrition, Cruces University Hospital, Barakaldo, País Vasco, Spain.
Roque Cardona-HernandezDivision of Pediatric Endocrinology, Hospital Sant Joan de Deu, Barcelona, Catalunya, Spain.
Fernando Gomez-PeraltaEndocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain.
Francisco Morales-PerezDepartment of Endocrinology and Nutrition, University Hospital Complex Badajoz, Badajoz, Extremadura, Spain.
Centro de Implantología Cirugía Oral y Maxilofacial · ESHospital de Cruces · ESHospital General De Segovia · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitario Puerta de Hierro Majadahonda · ESPharmacoeconomics and Health Outcomes Research Iberia (Spain) · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCompare cost of the interstitial liquid glucose flash monitoring (FM) system (FreeStyle Libre 2) versus self-monitoring of blood glucose (SMBG) in adults with type 1 diabetes mellitus (T1DM) in Spain. RESEARCH DESIGN AND

methodsA model was developed to estimate, with the perspective of the Spanish health system, the annual costs associated with glucose monitoring and hypoglycemic events management in T1DM population, with multiple insulin daily doses (MDI). According to published evidence, rate of severe hypoglycemia (SHE) of 4.90 episodes per patient-year was applied. Reduction of SHE (58.6%) was modeled associated with FM use. Published rates of hospital care (20.2%) and subsequent admission (16%) were assumed for SHE. The daily consumption of strips and lancets was 9 in patients with SMBG (before and after 4 daily intakes and at bedtime) and 0.5 for FM users (according to IMPACT trial findings). Annual consumption of 26 FM sensors was considered (1 every 14 days). Unit costs (in € of 2019, excluding VAT) were obtained from literature and national databases. Sensitivity analyses (SA) were carried out to evaluate the model robustness.

resultsThe total annual cost/patient was €4437 for SMBG and €2526 for FM. The use of FM would be associated with an annual savings in the costs of monitoring and managing hypoglycemic events of €1911 per patient-year. In a hypothetical cohort of 1000 patients with T1DM MDI, FM could avoid in 1 year 4900 SHE, 93 hospitalizations for SHE. In addition, the use of FM would generate total savings of up to €1 910 000 per year. In the SA with alternative hypoglycemia events rates and use of strips and lancets, and including non-SHE episodes, savings from €370 000 to €1 760 000 were observed with FM.

conclusionsThe use of the FM system to monitor glucose in adults with T1DM treated with MDI, would reduce hypoglycemic events and would result in cost savings for the health system.

Indexed as

Diabetes Mellitus, Type 1AdultBlood GlucoseBlood Glucose Self-MonitoringHumansHypoglycemic AgentsSpainBlood GlucoseHypoglycemic Agentsadult diabetescost(s)glucose monitoringtype 1

Identifiers

PMID32699114
PMCPMC7375427
OpenAlexW3045463944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.