Evidence map›Paper›PMID 32699111›Full record

ReviewThe Journal of biological chemistry2020

Brain cell somatic gene recombination and its phylogenetic foundations.

Gwendolyn Kaeser, Jerold Chun

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Cytogenomic epileptology.Molecular cytogenetics · 2023
    Review
  11. Article
  12. Somatic mosaicism in the diseased brain.Molecular cytogenetics · 2022
    Review
  13. Article
  14. Review
  15. Struggle within: evolution and ecology of somatic cell populations.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Review
  17. Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gwendolyn KaeserDegenerative Disease Program at the Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Jerold ChunDegenerative Disease Program at the Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA jchun@sbpdiscovery.org.ORCID 0000-0003-3964-0921
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brainsR01AG065541 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2020 to 2024
$4.8M
Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brainR01AG071465 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2020 to 2024
$4.6M
Transformative research on the normal and Alzheimer's disease brain through studies of neuronal gene recombinationR56AG067489 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2019 to 2019
$2.4M
NIA NIH HHS R01 AG065541NIA NIH HHS R01 AG071465NIA NIH HHS R56 AG067489
6 · The paper itself

Abstract

A new form of somatic gene recombination (SGR) has been identified in the human brain that affects the Alzheimer's disease gene, amyloid precursor protein (

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorLong Interspersed Nucleotide ElementsRecombination, GeneticRNA-Directed DNA PolymeraseBrainHumansAmyloid beta-Protein PrecursorAPP protein, humanRNA-Directed DNA PolymeraseAlzheimer diseasecopy-number variation (CNV)DNA recombinationgenomic mosaicismgenomicsintron lossneurodegenerative diseaseneuronneuronspostmitoticprocessed pseudogenesreverse transcriptionsingle-nucleotide variation (SNV)somatic cell geneticssomatic gene recombinationVDJ recombinationyeast geneticsyeast genomes

Identifiers

PMID32699111
PMCPMC7476723
OpenAlexW3043844096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.