Evidence map›Paper›PMID 32698876›Full record

ReviewMolecular medicine (Cambridge, Mass.)2020

Long non-coding RNA H19 in atherosclerosis: what role?

Xian Shi, Ya-Ting Wei, Heng Li, Ting Jiang, Xi-Long Zheng, Kai Yin, Guo-Jun Zhao

Open access · goldAbstract readReview
In one paragraph

Review in Molecular medicine (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Review
  9. Review
  10. The relationship between long noncoding RNAInternational journal of medical sciences · 2025
    Article
  11. Review
  12. Therapeutic Strategies for Angiogenesis Based on Endothelial Cell Epigenetics.Journal of cardiovascular translational research · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Long noncoding RNA (lncRNA)Genes & diseases · 2023
    Review
  18. Article
  19. Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Xian ShiSchool of Medicine, Guilin Medical University, Guilin, 541100, Guangxi, China.
Ya-Ting WeiSchool of Medicine, Guilin Medical University, Guilin, 541100, Guangxi, China.
Heng LiInstitute of Cardiovascular Research, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, 421001, Hunan, China.
Ting JiangThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, 511518, Guangdong, China.
Xi-Long ZhengDepartment of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, Calgary, AB, Canada.
Kai YinCenter for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541100, Guangxi, China. kaiyinby@qq.com.
Guo-Jun ZhaoThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, 511518, Guangdong, China. zzhcsu@163.com.ORCID 0000-0003-3030-4622
Guilin Medical University · CNGuangzhou Medical University · CNUniversity of Calgary · CAUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.

Indexed as

Gene Expression RegulationRNA InterferenceAdipocytesAnimalsApoptosisAtherosclerosisCell DifferentiationCell ProliferationDisease SusceptibilityGene Regulatory NetworksHumansLipid MetabolismRNA, Long NoncodingH19 long non-coding RNARNA, Long NoncodingAngiogenesisAtherosclerosisInflammatory responseLipid metabolismLncRNA-H19

Identifiers

PMID32698876
PMCPMC7374855
OpenAlexW3044868940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.