Evidence map›Paper›PMID 32698352›Full record

ReviewBioengineering (Basel, Switzerland)2020

Recent Trends in Injury Models to Study Skeletal Muscle Regeneration and Repair.

Sydnee T Sicherer, Rashmi S Venkatarama, Jonathan M Grasman

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

  1. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.bioRxiv : the preprint server for biology · 2026
    Article
  4. Hb-EGF directs systemic muscle repair.Development (Cambridge, England) · 2026
    Article
  5. Article
  6. Review
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  11. CNanomedicine (London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sydnee T SichererDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Rashmi S VenkataramaDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Jonathan M GrasmanDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.ORCID 0000-0001-8289-9627
New Jersey Institute of Technology · US

Funding

Institutional Career Development CoreKL2TR003018 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI CHAN, JOHN R., HALM, ETHAN A · 2019 to 2023
$3.0M
Acellular composite hydrogel scaffolds for volumetric muscle regenerationR21AR079708 · NIAMS · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI GRASMAN, JONATHAN M., KUMAR, VIVEK · 2022 to 2023
$467k
NCATS NIH HHS KL2 TR003018NIAMS NIH HHS R21 AR079708
6 · The paper itself

Abstract

Skeletal muscle injuries that occur from traumatic incidents, such as those caused by car accidents or surgical resections, or from injuries sustained on the battlefield, result in the loss of functionality of the injured muscle. To understand skeletal muscle regeneration and to better treat these large scale injuries, termed volumetric muscle loss (VML), in vivo injury models exploring the innate mechanisms of muscle injury and repair are essential for the creation of clinically applicable treatments. While the end result of a muscle injury is often the destruction of muscle tissue, the manner in which these injuries are induced as well as the response from the innate repair mechanisms found in muscle in each animal models can vary. This targeted review describes injury models that assess both skeletal muscle regeneration (i.e., the response of muscle to myotoxin or ischemic injury) and skeletal muscle repair (i.e., VML injury). We aimed to summarize the injury models used in the field of skeletal muscle tissue engineering, paying particular attention to strategies to induce muscle damage and how to standardize injury conditions for future experiments.

Indexed as

animal modelsskeletal muscle regenerationtissue engineeringvolumetric muscle loss

Identifiers

PMID32698352
PMCPMC7552705
OpenAlexW3042324713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.