ArticleNature2020
MeCP2 links heterochromatin condensates and neurodevelopmental disease.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132citing papers in PubMed
19.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
132 citing papers in PubMed, 197 citations in OpenAlex.
- Biomolecular Condensates Integrate Transcriptional and Epigenetic Responses to Hypoxia.International journal of molecular sciences · 2026Review
- Mega-enhancers compartmentalize transcriptionally active long genes in the brain.Nature cell biology · 2026Article
- High-throughput identification of endogenous biomolecular condensates and phase-separating proteins.Nature protocols · 2026Review
- Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2.eLife · 2026Article
- The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice.The EMBO journal · 2026Article
- MECP2Science China. Life sciences · 2026Article
- A machine learning framework for predicting and modulating condition-dependent protein phase separation.Nature communications · 2026Article
- Active RNA synthesis patterns nuclear condensates.Cell systems · 2026Article
- The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners.bioRxiv : the preprint server for biology · 2026Article
- Article
- MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome.Cell death & disease · 2026Article
- From chromosomal protein disorder to chromatin phase separation.Epigenetics & chromatin · 2026Review
- Cell-Penetrating Peptides and Supercharged Proteins: A Comprehensive Protocol from Isolation to Cellular Uptake.Molecular pharmaceutics · 2026Article
- Image-based epigenetic profiling with deep learning and high-speed super-resolution microscopy.Epigenetics & chromatin · 2026Article
- Absence of Ledgf in mouse brain affects the Kmt2a/b and polycomb balance, synaptic transmission and motor function.Acta neuropathologica communications · 2026Article
- Heterochromatome wide analyses reveal MBD2 as a phase separation scaffold for heterochromatin compartmentalization and composition.Nucleic acids research · 2025Article
- A molecular census to elucidate the demixing mechanism of membraneless organelles.Genome biology · 2025Article
- Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach.bioRxiv : the preprint server for biology · 2025Article
- Human MeCP2 binds to promoters and inhibits transcription in an unmethylated yeast genome.Genetics · 2025Article
- Biomolecular condensates in plant immunity.Cell host & microbe · 2025Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Charles H Li *Whitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8091-6112
Eliot L Coffey *Whitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6579-6527
Alessandra Dall'AgneseWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Nancy M HannettWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Xin TangWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jonathan E HenningerWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9604-2007
Jesse M PlattWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Ozgur OksuzWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Alicia V ZamudioWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Lena K AfeyanWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jurian SchuijersWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
X Shawn LiuWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Styliani MarkoulakiWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Tenzin LungjangwaWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Gary LeRoyDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Devon S SvobodaWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Emile WogramWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Tong Ihn LeeWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Rudolf JaenischWhitehead Institute for Biomedical Research, Cambridge, MA, USA. jaenisch@wi.mit.edu.ORCID http://orcid.org/0000-0002-2540-7099
Richard A YoungWhitehead Institute for Biomedical Research, Cambridge, MA, USA. young@wi.mit.edu.ORCID http://orcid.org/0000-0001-8855-8647
Whitehead Institute for Biomedical Research · USColumbia University Irving Medical Center · USMassachusetts General Hospital · USNew York University · USUniversity Medical Center Utrecht · NL
Funding
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MRESEARCH TRAINING IN DIGESTIVE DISEASES AND NUTRITIONT32DK007191 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1986 to 2026
$14.6MGENOMIC IMPRINTING AND THE CLONING OF MICER37CA084198 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2000 to 2008
$9.2MTranscriptional condensates, epigenetic editing and Rett SyndromeR01MH104610 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, YOUNG, RICHARD · 2014 to 2023
$7.4MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MTranscriptional regulatory networks in living cellsR01GM123511 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOUNG, RICHARD · 2017 to 2020
$3.6MRole of the Rett Syndrome-causing gene MeCP2 in 3D chromosomal organization and rescue of cellular disease phenotypesR00MH113813 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIU, X. SHAWN · 2020 to 2022
$735kRole of the Rett Syndrome-causing gene MeCP2 in 3D chromosomal organization and rescue of cellular disease phenotypesK99MH113813 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LIU, X. SHAWN · 2018 to 2019
$261kNCI NIH HHS R37 CA084198NIDDK NIH HHS T32 DK007191NIGMS NIH HHS R01 GM123511NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32 GM087237NIH HHS 2 R01 MH104610-20NIH HHS T32 5T3DK007191-45NIMH NIH HHS K99 MH113813NIMH NIH HHS R00 MH113813NIMH NIH HHS R01 MH104610
Abstract
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing
Indexed as
MutationAdaptive ImmunityAnimalsFemaleHeterochromatinImmunity, InnateIntellectual DisabilityMethyl-CpG-Binding Protein 2MiceNeuronsPhenotypeRett SyndromeHeterochromatinMECP2 protein, humanMethyl-CpG-Binding Protein 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.