Evidence map›Paper›PMID 32698033›Full record

Trial reportOphthalmology2020

The Role of Topical Antibiotic Prophylaxis in Oculofacial Plastic Surgery: A Randomized Controlled Study.

Davin C Ashraf, Oluwatobi O Idowu, Qinyun Wang, Tak YeEun, Thomas S Copperman, Sombat Tanaboonyawat, Benjamin F Arnold, Catherine E Oldenburg, M Reza Vagefi, Robert C Kersten

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Is topical antibiotic use necessary to prevent surgical site infection following oculoplastic surgery?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Davin C AshrafDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: davin.ashraf@ucsf.edu.
Oluwatobi O IdowuDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Qinyun WangDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Tak YeEunDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Thomas S CoppermanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Sombat TanaboonyawatDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California; Department of Ophthalmology, Phramongkutklao College of Medicine, Bangkok, Thailand.
Benjamin F ArnoldDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
Catherine E OldenburgDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California.
M Reza VagefiDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Robert C KerstenDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
University of California, San Francisco · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

purposeThe usefulness of topical antibiotic prophylaxis for routine oculofacial plastic surgery is not well established. Given concerns such as contact dermatitis, antibiotic resistance, and healthcare costs in conjunction with a low baseline rate of surgical site infections, the investigators sought to determine the frequency of infection with and without the use of topical antibiotic prophylaxis.

designRandomized, controlled, unmasked clinical trial.

participantsAdult patients undergoing routine periocular surgery without prior history of periocular surgical site infection, need for perioperative oral or parenteral antibiotics, or allergy to all study medications.

methodsParticipants were randomized before surgery to receive either antibiotic or placebo (mineral oil and petrolatum-based) ointment after surgery. Outcomes were measured at the first postoperative visit. The 2-tailed Fisher exact test was used to compare outcomes between groups.

main outcome measuresThe primary outcome was the incidence of surgical site infections. The secondary outcomes included stratification of infections by patient risk characteristics, incidence of allergic contact dermatitis, and incidence of wound complications.

resultsFour hundred one participants were enrolled and randomized, and 13 participants did not proceed with surgery or were lost to follow-up. High-risk features for infection were identified in 24% of the placebo group and 21% of the antibiotic group. Surgical site infections were more common in the placebo group (2.7% vs. 0.0%; P = 0.025). The rate of contact dermatitis was similar (0.5% vs. 0.5%; P = 1.00), as was the rate of wound dehiscence (2.7% vs. 3.5%; P = 0.77). Among the placebo group, the incidence of infections in the low- and high-risk participants was 2.9% and 2.2%, respectively. Infections were treated with oral or topical antibiotics and resolved without complication, except in 1 patient who required 2 subsequent surgeries to address the sequelae.

conclusionsAfter routine oculofacial plastic surgery, patients treated with a topical antibiotic ointment showed a lower risk of surgical site infection compared with patients treated with a nonantibiotic ointment.

Indexed as

Antibiotic ProphylaxisOphthalmologic Surgical ProceduresSurgery, PlasticAdolescentAdultAgedAged, 80 and overAnti-Infective Agents, LocalFaceFemaleHumansMaleMiddle AgedSurgical Wound InfectionYoung AdultAnti-Infective Agents, Localantibioticcontact dermatitiseyelidoculofacial plasticoculoplasticointmentperiocularprophylaxissurgerysurgical site infectionwound dehiscencewound infection

Identifiers

PMID32698033
PMCPMC7686086
OpenAlexW3042302461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.