Evidence map›Paper›PMID 32697988›Full record

ArticleCell reports2020

Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K

Michael C Lee, Michael S Nahorski, James R F Hockley, Van B Lu, Gillian Ison, Luke A Pattison, Gerard Callejo, Kaitlin Stouffer, Emily Fletcher, Christopher Brown and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  10. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Roles of PDGF/PDGFR signaling in various organs.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  12. KCNG4 Genetic Variant Linked to Migraine Prevents Expression of KCNB1.International journal of molecular sciences · 2024
    Article
  13. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  14. Article
  15. Article
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  17. Article
  18. Review
  19. IGF/IGF-1R signal pathway in pain: a promising therapeutic target.International journal of biological sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Michael C LeeUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: ml404@cam.ac.uk.
Michael S NahorskiCambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
James R F HockleyDepartment of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK.
Van B LuWellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Gillian IsonUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Luke A PattisonDepartment of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK.
Gerard CallejoDepartment of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK.
Kaitlin StoufferCambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Emily FletcherCambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Christopher BrownDepartment of Psychological Sciences, Institute of Psychology, Health and Society, University of Liverpool, Liverpool L69 7ZA, UK.
Ichrak DrissiUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Daniel WheelerUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Patrik ErnforsDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
David MenonUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Frank ReimannWellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fr222@cam.ac.uk.
Ewan St John SmithDepartment of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK. Electronic address: es336@cam.ac.uk.
C Geoffrey WoodsCambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: cw347@cam.ac.uk.
University of Cambridge · GBAddenbrooke's Hospital · GBLawn Tennis Association · GBWellcome/MRC Institute of Metabolic Science · GBDigital Catapult · GBKarolinska Institutet · SEUniversity of Liverpool · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M011194/1Biotechnology and Biological Sciences Research Council BB/R006210/1Medical Research Council MC_UU_12012/3Medical Research Council MRC_MC_UU_12012/3Medical Research Council MR/J012742/1Versus Arthritis 21973Wellcome TrustWellcome Trust 106262/Z/14/ZWellcome Trust 106263/Z/14/ZWellcome Trust 200183/Z/15/Z
6 · The paper itself

Abstract

By studying healthy women who do not request analgesia during their first delivery, we investigate genetic effects on labor pain. Such women have normal sensory and psychometric test results, except for significantly higher cuff pressure pain. We find an excess of heterozygotes carrying the rare allele of SNP rs140124801 in KCNG4. The rare variant K

Indexed as

AdultAllelesAmino Acid SequenceAnalgesicsAnimalsBase SequenceCell MembraneCognitionCohort StudiesEmotionsFemaleGanglia, SpinalHeterozygoteHumansIon Channel GatingLabor PainAnalgesicsKCNB1 protein, humanKCNG4 protein, humanPotassium Channels, Voltage-GatedProtein SubunitsShab Potassium Channelslabor pain, nociception, pain, Kv6.4, quantitative sensory testing, DRG neuron, exome sequencing

Identifiers

PMID32697988
PMCPMC7383234
OpenAlexW3044522922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.