ArticleMagnetic resonance in medicine2020
A variable resolution approach for improved acquisition of hyperpolarized
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic Imaging as Future Technology and Innovation in Brain-Tumour Surgery: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- From equilibrium to dynamic metabolic imaging: the evolving role of magnetic resonance spectroscopic imaging in neurodegenerative disorders.Journal of translational medicine · 2026Review
- Hyperpolarized MRI in Oncology-A Review of Clinical Studies and Evaluation of Preclinical Liver Studies.NMR in biomedicine · 2026Review
- Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis.Magnetic resonance in medicine · 2026Article
- Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025Review
- Hyperpolarized [1-Journal of magnetic resonance open · 2025Article
- Open-source implementation of X-nuclear sequences using the Pulseq framework.Magnetic resonance in medicine · 2025Article
- Spatially constrained hyperpolarized 13C MRI pharmacokinetic rate constant map estimation using a digital brain phantom and a U-Net.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- Hyperpolarized [1-Brain communications · 2025Article
- Translation of hyperpolarized [Npj imaging · 2025Article
- Simultaneous noninvasive quantification of redox and downstream glycolytic fluxes reveals compartmentalized brain metabolism.Science advances · 2024Article
- A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024Article
- Article
- A vendor-neutral EPI sequence for hyperpolarizedMagnetic resonance in medicine · 2024Article
- Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024Review
- Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-ACS sensors · 2024Article
- Advanced HyperpolarizedCancers · 2024Article
- Regional quantification of cardiac metabolism with hyperpolarized [1-Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Investigating cerebral perfusion with high resolution hyperpolarized [1-Magnetic resonance in medicine · 2023Article
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Authors and funding
13 authors.
Funding
Abstract
purposeTo ameliorate tradeoffs between a fixed spatial resolution and signal-to-noise ratio (SNR) for hyperpolarized
methodsIn MRI, SNR is proportional to voxel volume but retrospective downsampling or voxel averaging only improves SNR by the square root of voxel size. This can be exploited with a metabolite-selective imaging approach that independently encodes each compound, yielding high-resolution images for the injected substrate and coarser resolution images for downstream metabolites, while maintaining adequate SNR for each. To assess the efficacy of this approach, hyperpolarized [1-
resultsCompared with a constant resolution acquisition, variable-resolution data sets showed improved detectability of metabolites in pre-clinical renal studies with a 3.5-fold, 8.7-fold, and 6.0-fold increase in SNR for lactate, alanine, and bicarbonate data, respectively. Variable-resolution data sets from healthy human subjects showed cardiac structure and neuro-vasculature in the higher resolution pyruvate images (6.0 × 6.0 mm
conclusionWe developed a variable-resolution strategy for hyperpolarized
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