Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Improving the Delivery of Chronic Opioid Therapy Among People Living With Human Immunodeficiency Virus: A Cluster Randomized Clinical Trial.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Toward Safer Opioid Prescribing in HIV care (TOWER): a mixed-methods, cluster-randomized trial.Addiction science & clinical practice · 2022Trial
- A collaborative care intervention to improve opioid prescribing among providers caring for persons with HIV: Impact on satisfaction, confidence, and trust.Drug and alcohol dependence · 2022Trial
- Hazardous alcohol use is associated with greater pain interference and prescription opioid misuse among persons living with HIV and chronic pain.BMC public health · 2021Trial
- Article
- Opioid risk-reduction strategies for people with HIV on chronic opioid therapy: A qualitative study of patient perspectives.SSM. Mental health · 2024Article
- Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods.Addiction science & clinical practice · 2023Article
- So What Do We Do Now? New Opioid Prescribing Guidelines, Implementation Science, and How to Improve the Care of Patients Receiving Long-Term Opioid Therapy in Primary Care.Journal of general internal medicine · 2023Article
- So What Do We Do Now? New Opioid Prescribing Guidelines, Implementation Science, and How to Improve the Care of Patients Receiving Long-Term Opioid Therapy in Primary Care.Journal of general internal medicine · 2023Article
- Functional Impairment and Cognitive Symptoms Among People with HIV Infection on Chronic Opioid Therapy for Pain: The Impact of Gabapentin and Other Sedating Medications.AIDS and behavior · 2022Article
- Exploring perspectives on changing opioid prescribing practices: A qualitative study of community stakeholders in the HEALing Communities Study.Drug and alcohol dependence · 2022Article
- The effects of an evidence- and theory-informed feedback intervention on opioid prescribing for non-cancer pain in primary care: A controlled interrupted time series analysis.PLoS medicine · 2021Article
- Race and satisfaction with pain management among patients with HIV receiving long-term opioid therapy.Drug and alcohol dependence · 2021Article
- Academic detailing interventions for opioid-related outcomes: a scoping review.Drugs in context · 2021Article
- Influence of patient trust in provider and health literacy on receipt of guideline-concordant chronic opioid therapy in HIV care settings.Journal of opioid managementArticle
- Emergency Department Utilization Among People Living With HIV on Chronic Opioid Therapy.Journal of the International Association of Providers of AIDS CareObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundChronic pain is prevalent among people living with human immunodeficiency virus (PLWH); managing pain with chronic opioid therapy (COT) is common. Human immunodeficiency virus (HIV) providers often diverge from prescribing guidelines.
methodsThis 2-arm, unblinded, cluster-randomized clinical trial assessed whether the Targeting Effective Analgesia in Clinics for HIV (TEACH) intervention improves guideline-concordant care compared to usual care for PLWH on COT. The trial was implemented from 2015 to 2018 with 12-month follow-up at safety-net hospital-based HIV clinics in Boston and Atlanta. We enrolled 41 providers and their 187 patients on COT. Prescribers were randomized 1:1 to either a 12-month intervention consisting of a nurse care manager with an interactive electronic registry, opioid education, academic detailing, and access to addiction specialists or a control condition consisting of usual care. Two primary outcomes were assessed through electronic medical records: ≥2 urine drug tests and any early COT refills by 12 months. Other outcomes included possible adverse consequences.
resultsAt 12 months, the TEACH intervention arm had higher odds of ≥2 urine drug tests than the usual care arm (71% vs 20%; adjusted odds ratio [AOR], 13.38 [95% confidence interval {CI}, 5.85-30.60]; P < .0001). We did not detect a statistically significant difference in early refills (22% vs 30%; AOR, 0.55 [95% CI, .26-1.15]; P = .11), pain severity (6.30 vs 5.76; adjusted mean difference, 0.10 [95% CI, -1.56 to 1.75]; P = .91), or HIV viral load suppression (86.9% vs 82.1%; AOR, 1.21 [95% CI, .47-3.09]; P = .69).
conclusionsTEACH is a promising intervention to improve adherence to COT guidelines without evident adverse consequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.