ArticleEndocrinology2020
RNA-Seq Reveals Sub-Zones in Mouse Adrenal Zona Fasciculata and the Sexually Dimorphic Responses to Thyroid Hormone.
Article in Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.Nature communications · 2026Article
- The Transcriptome Trajectory Reveals Sex- and Age-Dependent Changes in the Mouse Adrenal Gland.Aging cell · 2025Article
- Adrenal lipoma formation via PI(3,4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.Frontiers in microbiology · 2025Article
- Current insight into the transient X-zone in the adrenal gland cortex.Vitamins and hormones · 2024Review
- DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex.International journal of molecular sciences · 2023Article
- Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex.International journal of molecular sciences · 2022Review
- Early transcriptomic response of mouse adrenal gland and Y-1 cells to dexamethasone.Endocrine connections · 2022Article
- Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function.Thyroid : official journal of the American Thyroid Association · 2022Article
- Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function.The Journal of clinical investigation · 2022Article
- Whole Transcriptome Profiling of Adrenocortical Tumors Using Formalin-Fixed Paraffin-Embedded Samples.Frontiers in endocrinology · 2022Article
- Isolate Cell-Type-Specific RNAs from Snap-Frozen Heterogeneous Tissue Samples without Cell Sorting.Journal of visualized experiments : JoVE · 2021Article
- Integrative genomic analysis reveals a conserved role for prolactin signalling in the regulation of adrenal function.Clinical and translational medicine · 2021Article
- RNA-Seq Reveals Sub-Zones in Mouse Adrenal Zona Fasciculata and the Sexually Dimorphic Responses to Thyroid Hormone.Endocrinology · 2020Article
- NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms.Reproductive medicine and biologyReview
- DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.Technology in cancer research & treatmentReview
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
The sex-specific prevalence of adrenal diseases has been known for a long time. However, the reason for the high prevalence of these diseases in females is not completely understood. Mouse studies have shown that the adult adrenal gland is sexually dimorphic at different levels such as transcriptome, histology, and cell renewal. Here we used RNA-seq to show that in prepubertal mice, male and female adrenal glands were not only sexually dimorphic but also responded differently to the same external stimulus. We previously reported that thyroid hormone receptor β1 (TRβ1) in the adrenal gland is mainly expressed in the inner cortex and the fate of this TRβ1-expressing cell population can be changed by thyroid hormone (triiodothyronine; T3) treatment. In the present study, we found that adrenal glands in prepubertal mice were sexually dimorphic at the level of the transcriptome. Under T3 treatment, prepubertal females had 1162 genes differentially expressed between the saline and T3 groups, whereas in males of the same age, only 512 genes were T3-responsive. Immunostaining demonstrated that several top sexually dimorphic T3-responsive genes, including Cyp2f2 and Dhcr24, were specifically expressed in the adrenal inner cortex, precisely in an area partially overlapping with the X-zone. Under T3 treatment, a unique cortical layer that surrounds the adrenal X-zone expanded significantly, forming a distinct layer peculiar to females. Our findings identified novel marker genes for the inner adrenal cortex, indicating there are different sub-zones in the zona fasciculata. The results also highlight the sex-specific response to thyroid hormone in the mouse adrenal gland.
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Registered trials
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