SynthesisAging2020
Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Exploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty.Clinical epigenetics · 2026Article
- DNA methylation predicts adverse outcomes of coronary artery disease.Nature communications · 2025Article
- Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma.Aging cell · 2025Article
- Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age.Genome biology · 2025Article
- DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data.Journal of translational medicine · 2023Article
- Article
- Refining epigenetic prediction of chronological and biological age.Genome medicine · 2023Article
- Metals Exposures and DNA Methylation: Current Evidence and Future Directions.Current environmental health reports · 2022Review
- Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease.Scientific reports · 2022Article
- The relationship between ageing and changes in the human blood and brain methylomes.NAR genomics and bioinformatics · 2022Article
- Pre-diagnosis neutrophil-to-lymphocyte ratio and mortality in individuals who develop lung cancer.Cancer causes & control : CCC · 2021Article
- Commentary: Novel strategies and new tools to curtail the health effects of pesticides.Environmental health : a global access science source · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors.
Elena ColicinoIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Riccardo MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Cavin Ward-CavinessUS Environmental Protection Agency, Chapel Hill, NC 27514, USA.
Rahul GondaliaGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Brian ChenLongitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Tianxiao HuanNational Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Gao XuColumbia University Mailman School of Public Health, New York, NY 10032, USA.
Agha GolarehColumbia University Mailman School of Public Health, New York, NY 10032, USA.
Joel SchwartzHarvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Pantel VokonasVA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston, MA 02115, USA.
Allan JustIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
John M StarrAlzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Allan F McRaeInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Naomi R WrayInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Peter M VisscherInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Jan BresslerUniversity of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Wen ZhangDepartment of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Toshiko TanakaLongitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA.
Ann Zenobia MooreLongitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA.
Luke C PillingEpidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK.
Guosheng ZhangDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA.
James D StewartGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
Yun LiGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
Lifang HouFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Juan Castillo-FernandezDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Tim SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Douglas P KielHebrew SeniorLife Institute for Aging Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA 02215, USA.
Joanne M MurabitoSection General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02215, USA.
Chunyu LiuBoston University School of Public Health, Boston, MA 02215, USA.
Mike MendelsonBoston University School of Medicine, Boston, MA 02215, USA.
Tim AssimesStanford University School of Medicine, Stanford, CA 94305, USA.
Devin AbsherHudson Alpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Phil S TsahoDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Luigi FerrucciNational Institute of Aging, Bethesda, MD 20892, USA.
Rory WilsonResearch Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Holger ProkischInstitute of Human Genetics, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg S-85764, Germany.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Daniel LevyFramingham Heart Study, Framingham, MA 01702, USA.
Ian J DearyDepartment of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jim PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Annette PetersInstitute for Epidemiology II, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Eric A WhitselGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
Andrea BaccarelliColumbia University Mailman School of Public Health, New York, NY 10032, USA.
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MTrue Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MRISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MEpigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8MAir Particulate, Metals, and Cognitive Performance in an Aging Cohort- Roles of Circulating Extracellular Vesicles and Non-coding RNAsR01ES027747 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2017 to 2021
$3.7MEpigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0MCirculating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging CohortR01ES025225 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA · 2016 to 2020
$2.9MAn Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel DiseaseR01NS087541 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A., FORNAGE, MYRIAM · 2014 to 2017
$2.5MMolecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4MMedical Research Council MR/K026992/1NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL105756NHLBI NIH HHS RC2 HL102419NIAMS NIH HHS R01 AR041398NIA NIH HHS HHSN271201100004CNIA NIH HHS R56 AG029451NIA NIH HHS U34 AG051418NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES014663NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES020836NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R01 ES025225NIEHS NIH HHS R01 ES027747NIEHS NIH HHS R21 ES020010NIMHD NIH HHS R01 MD009164NINDS NIH HHS R01 NS087541Wellcome TrustWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
DNA methylation has fundamental roles in gene programming and aging that may help predict mortality. However, no large-scale study has investigated whether site-specific DNA methylation predicts all-cause mortality. We used the Illumina-HumanMethylation450-BeadChip to identify blood DNA methylation sites associated with all-cause mortality for 12, 300 participants in 12 Cohorts of the Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium. Over an average 10-year follow-up, there were 2,561 deaths across the cohorts. Nine sites mapping to three intergenic and six gene-specific regions were associated with mortality (
Indexed as
DNA MethylationPredictive Value of TestsAdultAgedAgingCause of DeathChromosome MappingChronic DiseaseCohort StudiesEpigenesis, GeneticFemaleFollow-Up StudiesGenome-Wide Association StudyHumansLongitudinal StudiesMale450Kagingall-cause mortalityDNA methylationepigenome-wide association studies
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