ArticleJournal of affective disorders2020
Person-based similarity in brain structure and functional connectivity in bipolar disorder.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Structural brain variability in recent-onset and chronic schizophrenia: evidence from person-based similarity index analysis.Acta neuropsychiatrica · 2025Article
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum.Schizophrenia (Heidelberg, Germany) · 2024Article
- What Came First, Mania or Depression? Polarity at Onset in Bipolar I and II: Temperament and Clinical Course.Brain sciences · 2023Article
- Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance.Molecular autism · 2023Article
- Aberrant neurophysiological signaling associated with speech impairments in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.NeuroImage. Clinical · 2023Article
- Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.Translational psychiatry · 2022Article
- Person-Based Similarity Index for Cognition and Its Neural Correlates in Late Adulthood: Implications for Cognitive Reserve.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The Impact of Lithium on Brain Function in Bipolar Disorder: An Updated Review of Functional Magnetic Resonance Imaging Studies.CNS drugs · 2021Review
- Personalized Estimates of Brain Structural Variability in Individuals With Early Psychosis.Schizophrenia bulletin · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundBipolar disorder shows significant variability in clinical presentation. Here we adopt a personalized approach to quantify the brain structural and functional similarity of each individual patient to other patients and to healthy individuals.
methodsBrain morphometric and resting-state functional connectivity measures from two independent samples of patients with bipolar disorder and healthy individuals (total number of participants=215) were modeled as single vectors to generated individualized morphometric and connectivity profiles. These profiles were then used to compute a person-based similarity indices which quantified the similarity in neuroimaging profiles amongst patients and between patients and health individuals.
resultsThe morphometric and connectivity profiles of patients showed within-diagnosis similarity which was comparable to that observed in healthy individuals. They also showed minimal deviance from those of healthy individuals; the correlation between the profiles of patients and healthy individuals was high (range: 0.71-0.94, p<10 LIMITATIONS: We focused on patients with Bipolar disorder, type I only.
conclusionsHigh inter-individual similarity in neuroimaging profiles was observed amongst patients with bipolar disorder and between patients and healthy individuals. We infer that brain alterations associated with bipolar disorder may be nested within the normal biological diversity consistent with the high prevalence of mood symptoms in the general population.
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