Evidence map›Paper›PMID 32697670›Full record

ArticleJournal of neurophysiology2020

Fibrinogen-cellular prion protein complex formation on astrocytes.

Mariam Charkviani, Nino Muradashvili, Nurul Sulimai, David Lominadze

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Fibrinogen Interaction with Astrocyte ICAM-1 and PrPInternational journal of molecular sciences · 2021
    Article
  9. Article
  10. Review
  11. Fibrinogen and/or Fibrin as a Cause of Neuroinflammation.Online journal of neurology and brain disorders · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mariam CharkvianiDepartment of Physiology, University of Louisville, School of Medicine, Louisville, Kentucky.
Nino MuradashviliDepartment of Physiology, University of Louisville, School of Medicine, Louisville, Kentucky.
Nurul SulimaiDepartment of Surgery, USF Health-Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0003-1590-5710
David LominadzeDepartment of Physiology, University of Louisville, School of Medicine, Louisville, Kentucky.
University of Louisville · USUniversity of South Florida · US

Funding

Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque FormationR01NS084823 · NINDS · UNIVERSITY OF LOUISVILLE · PI LOMINADZE, DAVID, TYAGI, SURESH C. · 2013 to 2017
$2.7M
Mechanisms of neurodegeneration by a fibrinogen-containing protein complex during traumatic brain injuryR01HL146832 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LOMINADZE, DAVID · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL146832NINDS NIH HHS R01 NS084823
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is one of the most common neurological disorders causing memory reduction, particularly short-term memory (STM). We showed that, during TBI-induced inflammation, increased blood content of fibrinogen (Fg) enhanced vascular protein transcytosis and deposition of extravasated Fg in vasculo-astrocyte interfaces. In addition, we found that deposition of cellular prion protein (PrP

Indexed as

Brain ContusionCerebral CortexAnimalsAstrocytesCells, CulturedFibrinogenImmunoglobulin GMembrane GlycoproteinsMiceNitric OxidePrion ProteinsProtein-Tyrosine KinasesReactive Oxygen SpeciesReceptor, trkBUp-RegulationFibrinogenImmunoglobulin GMembrane GlycoproteinsNitric OxideNtrk2 protein, mousePrion ProteinsProtein-Tyrosine KinasesReactive Oxygen SpeciesReceptor, trkBastrocytescortical contusion injuryFg-PrPC complextraumatic brain injurytyrosine (tropomyosin) receptor kinase B

Identifiers

PMID32697670
PMCPMC7500368
OpenAlexW3045459208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.