Evidence map›Paper›PMID 32697629›Full record

ArticleMolecular biology of the cell2020

The conserved AAA-ATPase PCH-2

Lénaïg Défachelles, Anna E Russo, Christian R Nelson, Needhi Bhalla

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lénaïg DéfachellesDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.
Anna E RussoDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.
Christian R NelsonDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.
Needhi BhallaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.
University of California, Santa Cruz · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
The Synapsis Checkpoint in C. elegans MeiosisR01GM097144 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BHALLA, NEEDHI · 2011 to 2020
$2.8M
NIGMS NIH HHS R01 GM097144NIGMS NIH HHS T32 GM008646NIH HHS P40 OD010440
6 · The paper itself

Abstract

Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume, and cell fate. We show that the conserved AAA-ATPase PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive one, controls checkpoint strength in

Indexed as

Adaptor Proteins, Signal TransducingAdenosine TriphosphatasesAnimalsATPases Associated with Diverse Cellular ActivitiesCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsCell Cycle CheckpointsCell Cycle ProteinsKinetochoresMad2 ProteinsM Phase Cell Cycle CheckpointsNuclear ProteinsProtein BindingProtein ConformationSpindle ApparatusAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesCaenorhabditis elegans ProteinsCarrier ProteinsCell Cycle ProteinsMad2 ProteinsNuclear ProteinsPCH-2 protein, C elegans

Identifiers

PMID32697629
PMCPMC7550697
OpenAlexW3044942268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.