Evidence map›Paper›PMID 32697404›Full record

ArticleJournal of clinical laboratory analysis2020

Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma.

Yijun Liu, Qingluan Liu, Zhicheng Wang, Meilin Chen, Yi Chen, Xiayu Li, Donghai Huang, Songqing Fan, Wei Xiong, Guiyuan Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Immunohistochemical Expression and Clinical Significance of WWP1 Protein in Nasopharyngeal Cancer.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
  2. Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yijun LiuDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.
Qingluan LiuDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhicheng WangDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.
Meilin ChenDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.
Yi ChenDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiayu LiThe Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
Donghai HuangXiangya Hospital, Central South University, Changsha, China.
Songqing FanDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
Wei XiongThe Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
Guiyuan LiThe Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
Wenling ZhangDepartment of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0002-1586-6363
Central South University · CN

Funding

Central South University Innovation Foundation for Postgraduate 2019zzts777Central South University Innovation Foundation for Undergraduate 201910533306National Natural Science Foundation of China 81372907National Natural Science Foundation of China 81472531National Natural Science Foundation of China 81472595National Natural Science Foundation of China 81672683National Natural Science Foundation of China 81672688National Natural Science Foundation of China 81772928
6 · The paper itself

Abstract

backgroundCyclin D1 is an essential part of oncogenic transformation. We previously proved that cyclin D1 was upregulated in nasopharyngeal carcinoma (NPC) and promoted the NPC cell proliferation. But the association between cyclin D1 and the clinical outcome of NPC has not yet been determined. The study explores the possible relevance between the cyclin D1 expression and clinical parameters and its predictive value of prognosis in NPC patients.

methodsWe analyzed the clinical data from 379 NPC patients and 112 non-NPC patients in our previous study, which made further statistics. Receiver operating curve (ROC) was applied to select the optimal cutoff points. By analyzing the clinical data from 101 NPC patients using Chi-squared test, we estimated the relationship between the cyclin D1 expression level and clinicopathological parameters. We also used Kaplan-Meier method and log-rank test assess and compared the disease-free survival (DFS) rate and overall survival (OS) rate. The Cox proportional hazards model was adopted to perform the univariate and multivariate analyses.

resultReceiver operating curve analysis reported that cyclin D1 was used to differentiate between NPC patients and non-NPC patients (P < .001, sensitivity: 53.6%, specificity: 85.7%, AUC = 0.752). Cyclin D1 was positively correlated with lymph node metastasis (P = .015). A survival analysis of the 101 NPC patients indicated that the positive expression of cyclin D1 was predictive of a good prognosis (DFS: P = .010, OS: P = .019). Multivariate analysis showed that cyclin D1 could be used independently to predict NPC patients' prognosis (DFS: P = .038).

conclusionThe overexpression of cyclin D1 is a good prognostic marker for NPC.

Indexed as

Cyclin D1Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisSurvival AnalysisUp-RegulationYoung AdultBiomarkers, TumorCCND1 protein, humanCyclin D1cyclin D1markernasopharyngeal carcinomaprognosissurvival rate

Identifiers

PMID32697404
PMCPMC7439355
OpenAlexW3044212466

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.