ArticleMedical education2021
Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers.
Article in Medical education, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 99 citations in OpenAlex.
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- Validity and reliability of the Japanese Behavior Rating Inventory of Executive Function-Adult Version: Gender differences and age variations in adults.Journal of neuropsychology · 2026Article
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- Impact of an Asynchronous Fatigue Mitigation Curriculum for Graduate Medical Education.ATS scholar · 2026Article
- Targeting the YY1/HDAC2 Transcriptional Axis by Neferine Ameliorates Sleep Deprivation-Induced Cognitive Deficits.Neurochemical research · 2026Article
- A U-shaped association between sleep duration and depression in adult prescription opioid users.Frontiers in psychiatry · 2026Article
- Teaching common cognitive biases and associated errors in veterinary neurologic diagnosis using clinical vignettes: a narrative review.Frontiers in veterinary science · 2026Review
- Napping restores working memory and brain activation impaired by sleep deprivation.IBRO neuroscience reports · 2025Article
- Development and validation of a clinical sleep assessment tool for patients with cancer during treatment.Asia-Pacific journal of oncology nursing · 2025Article
- Incompleteness of the circle of Willis affects sleep quality, cognitive function and inflammation in patients with primary hypertension.The journal of physiological sciences : JPS · 2025Article
- The Recovery Deficit: A Simulation Model of Physician Performance Under Sleep Deprivation.Cureus · 2025Article
- Sleep Quality and Duration Can Influence Junior Physicians' Performance in High-Level Assessments for Residency Programs.Sleep science (Sao Paulo, Brazil) · 2025Article
- Atherogenic Risk in Shift Versus Non-Shift Workers: Associations with Sociodemographic and Lifestyle Factors.Diseases (Basel, Switzerland) · 2025Article
- Impact of shift durations on sleep, fatigue, and wellness among neonatologists: a cross-sectional survey analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Sleep traits and risk of premature ovarian insufficiency - two-sample and multivariate mendelian randomisation analysis.Przeglad menopauzalny = Menopause review · 2025Article
- A survey on mental health among resident physicians: psychological resilience as a mediator.BMC psychiatry · 2025Article
- The relationship between sleep deprivation and the worsening of mood disorders in health professionals working night shifts.Dementia & neuropsychologia · 2025Article
- Prevalence and contributory factors to burnout in the New Zealand surgical specialist and registrar population.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesInsufficient sleep affects circadian hormonal profiles and inflammatory markers and may modulate attention, executive functioning and decision-making. Medical professionals and specifically resident physicians, who are involved in long-term nightshift schedules during their post-graduate training, are prone to acute and chronic sleep deprivation and disruption, putting them at risk for making medical errors. The aim of the study was to evaluate the impact of chronic and acute-on-chronic sleep deprivation and disruption among residents on selected physiological and cognitive measures.
methodsThirty-three medical and surgical residents were evaluated twice - at baseline and after a 26-hour shift. Eighteen young attending physicians who did not engage in nightshift schedules served as controls and were evaluated once. Measures included morning cortisol and high-sensitivity C-reactive protein (hs-CRP), computerised tests of attention and behaviour, the Behaviour Rating Inventory of Executive Function, a risk-taking questionnaire and the Pittsburgh Sleep Quality Index.
resultsResidents, but not attendings, reported chronic sleep disruption and deprivation. Residents at baseline exhibited reduced morning cortisol levels and elevated hs-CRP levels, compared to attendings. Residents at baseline had impaired global executive function compared to attendings. A nightshift with acute sleep deprivation further reduced residents' executive function. Residents at baseline and after a nightshift demonstrated increased impulsivity and slower processing time than attendings. Residents and attendings did not differ in risk-taking tendencies which were assessed in a separate cohort.
conclusionsIn a real-life setting, resident physicians exhibit increased low-grade systemic inflammation (hs-CRP) and impaired HPA-axis function. Their chronic sleep curtailment is associated with greater impulsivity, slower cognitive processing, and impaired executive function. Future research is warranted to understand how improving working schedule by increasing sleep duration may minimise the short-term and potential long-term risks to physicians in training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.