ArticleEnvironmental health perspectives2020
Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 142 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 249 citations in OpenAlex.
- Reduced organic nitrogen compounds dominate the toxicity of PMScience advances · 2026Article
- Known and Novel Per/Polyfluoroalkyl Substances (PFASs) in Serum of Tucson (AZ) Firefighters.Environmental science & technology · 2026Article
- GenX exposure induces neurodevelopmental impairment and synaptic toxicity in hESC-derived cerebral organoids.Materials today. Bio · 2026Article
- Development of a sample preparation protocol for fast fluorine screening of sealing materials-Considering potential PFAS regulations.Analytical and bioanalytical chemistry · 2026Article
- Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS.Archives of toxicology · 2026Article
- Global Inventory of Fluoropolymer Production Plants and Their Associated PFAS Environmental Contamination.Environmental science & technology · 2026Article
- Predifferentiation Neurotoxicity of GenX Exposure on hiPSC-Derived Cortical Neurons.Environmental science & technology · 2026Article
- Serum per- and polyfluoroalkyl substances (PFAS) concentrations and anti-spike SARS-CoV-2 IgG levels following COVID-19 vaccination: A cross-sectional study in three communities with elevated PFAS exposure.International journal of hygiene and environmental health · 2026Article
- Exposomics as a discovery engine for emerging contaminants and hidden biological risks.Emerging contaminants · 2026Article
- Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.Frontiers in toxicology · 2026Article
- How can academic researchers more effectively contribute to environmental toxicology and health efforts for regulatory decisions, policymakers, nonprofits, and communities?Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- Maternal, fetal, and neonatal toxicity and potency estimates of perfluorohexane sulfonate (PFHxS) from oral maternal exposure in the Sprague-Dawley rat.Toxicology · 2025Article
- Review
- Environmental behavior and human health risks of PFAS: occurrence, toxicity, and the state-of-the-art removal approaches.RSC advances · 2025Review
- Historical Blood Serum Samples from Wilmington, North Carolina: The Importance of Ultrashort-Chain Per- and Polyfluoroalkyl Substances.Environmental science & technology · 2025Article
- Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells.Environmental research · 2025Article
- From carboxylates to chlorinated sulfonates: Contrasting fate and treatment prospects of GenX and F53B in WWTPs.The Science of the total environment · 2025Review
- Emerging toxicological awareness of per- and polyfluoroalkyl substances: the rising concern over 'forever chemicals'.Disease models & mechanisms · 2025Review
- Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: Cross-sectional analysis results from the STRIVE cohort.Environmental research · 2025Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
17 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundFrom 1980 to 2017, a fluorochemical manufacturing facility discharged wastewater containing poorly understood per- and polyfluoroalkyl substances (PFAS) to the Cape Fear River, the primary drinking water source for Wilmington, North Carolina, residents. Those PFAS included several fluoroethers including HFPO-DA also known as GenX. Little is known about the bioaccumulation potential of these fluoroethers.
objectiveWe determined levels of fluoroethers and legacy PFAS in serum samples from Wilmington residents.
methodsIn November 2017 and May 2018, we enrolled 344 Wilmington residents
resultsParticipants' ages ranged from 6 to 86 y, and they lived in the lower Cape Fear Region for 20 y on average (standard deviation: 16 y). Six fluoroethers were detected in serum; Nafion by-product 2, PFO4DA, and PFO5DoA were detected in
conclusionPoorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. Health implications of exposure to these novel PFAS have not been well characterized. https://doi.org/10.1289/EHP6837.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.