Evidence map›Paper›PMID 32696994›Full record

ArticleImmunology and cell biology2020

Toll-like receptor 2 activation induces C-C chemokine receptor 2-dependent natural killer cell recruitment to the peritoneum.

Ian D Haidl, Dihia Meghnem, Thomas B Issekutz, Jean S Marshall

Open access · hybridAbstract read
In one paragraph

Article in Immunology and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ian D HaidlDalhousie Human Immunology and Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.
Dihia MeghnemDalhousie Human Immunology and Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.
Thomas B IssekutzDalhousie Human Immunology and Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.
Jean S MarshallDalhousie Human Immunology and Inflammation Group, Dalhousie University, Halifax, Nova Scotia, Canada.
Dalhousie University · CA

Funding

CIHR MOP10966CIHR MOP93517
6 · The paper itself

Abstract

Natural killer (NK) cells are innate effector cells with critical roles not only in tumor immunosurveillance and viral immunity, but also in bacterial and fungal infections. Toll-like receptor 2 (TLR2) can be important in the early and sustained immune responses to pathogens and tumors through the induction of cytokines and chemokines that recruit and activate immune effector cells. We investigated the role of TLR2 activation in NK cell recruitment with a view to informing approaches to induce or regulate peritoneal NK cell responses therapeutically. Peritoneal injection of TLR2 activators, including peptidoglycan and the lipopeptides FSL-1 and Pam

Indexed as

PeritoneumToll-Like Receptor 2AnimalsFemaleKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR2Ccr2 protein, mouseReceptors, CCR2Tlr2 protein, mouseToll-Like Receptor 2Inflammationinnate immunitylipopeptidepattern recognition receptor

Identifiers

PMID32696994
PMCPMC7754274
OpenAlexW3045076592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.