Evidence map›Paper›PMID 32696443›Full record

ReviewAdvances in experimental medicine and biology2021

The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review.

Matteo Paganini, Gerardo Bosco, Filippo A G Perozzo, Eva Kohlscheen, Regina Sonda, Franco Bassetto, Giacomo Garetto, Enrico M Camporesi, Stephen R Thom

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
52.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Matteo PaganiniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Gerardo BoscoDepartment of Biomedical Sciences, University of Padova, Padova, Italy. gerardo.bosco@unipd.it.
Filippo A G PerozzoPlastic and Reconstructive Surgery Unit, Padova University Hospital, Padova, Italy.
Eva KohlscheenPlastic and Reconstructive Surgery Unit, Padova University Hospital, Padova, Italy.
Regina SondaPlastic and Reconstructive Surgery Unit, Padova University Hospital, Padova, Italy.
Franco BassettoPlastic and Reconstructive Surgery Unit, Padova University Hospital, Padova, Italy.
Giacomo GarettoATIP Hyperbaric Medical Center, Padova, Italy.
Enrico M CamporesiTeamhealth Anesthesia Attending, Emeritus Professor of Surgery, USA, Tampa, FL, USA.
Stephen R ThomEmergency Medicine, University of Maryland, Baltimore, MD, USA.
University of Padua · ITUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent coronavirus disease 2019 (COVID-19) pandemic produced high and excessive demands for hospitalizations and equipment with depletion of critical care resources. The results of these extreme therapeutic efforts have been sobering. Further, we are months away from a robust vaccination effort, and current therapies provide limited clinical relief. Therefore, several empirical oxygenation support initiatives have been initiated with intermittent hyperbaric oxygen (HBO) therapy to overcome the unrelenting and progressive hypoxemia during maximum ventilator support in intubated patients, despite high FiO2. Overall, few patients have been successfully treated in different locations across the globe. More recently, less severe patients at the edge of impending hypoxemia were exposed to HBO preventing intubation and obtaining the rapid resolution of symptoms. The few case descriptions indicate large variability in protocols and exposure frequency. This summary illustrates the biological mechanisms of action of increased O

Indexed as

COVID-19COVID-19 Drug TreatmentHyperbaric OxygenationHumansOxygenSARS-CoV-2OxygenCOVID-19Hyperbaric oxygen therapyHypoxemiaInflammation

Identifiers

PMID32696443
OpenAlexW3045390145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.