Evidence map›Paper›PMID 32696437›Full record

ArticleNeurotoxicity research2020

Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex.

Regina Célia Cussa Kubrusly, Robertta Silva Martins, Lisiane de Santana Souza, Mariana Pinheiro de Carvalho, Vladimir Pedro Peralva Borges-Martins, Matheus Figueiredo Sathler, Danielle Dias Pinto Ferreira, Maurício Dos Santos Pereira, Ney Ronner Peccinalli, Pablo Pandolfo and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Regina Célia Cussa KubruslyLaboratório de Neurofarmacologia, Instituto Biomédico - Bloco E, Rua São João Batista 187, sala 428, Centro, Niteroi, RJ, CEP 24020-005, Brazil. reginakubrusly1@gmail.com.ORCID https://orcid.org/0000-0002-6016-2197
Robertta Silva MartinsLaboratório de Neurofarmacologia, Instituto Biomédico - Bloco E, Rua São João Batista 187, sala 428, Centro, Niteroi, RJ, CEP 24020-005, Brazil.ORCID https://orcid.org/0000-0002-7177-7226
Lisiane de Santana SouzaLaboratório de Neurobiologia do Comportamento Animal, Instituto de Biologia, Universidade Federal Fluminense, Niteroi, Brazil.ORCID https://orcid.org/0000-0001-5060-0088
Mariana Pinheiro de CarvalhoLaboratório de Neurofarmacologia, Instituto Biomédico - Bloco E, Rua São João Batista 187, sala 428, Centro, Niteroi, RJ, CEP 24020-005, Brazil.
Vladimir Pedro Peralva Borges-MartinsLaboratório de Neurofarmacologia, Instituto Biomédico - Bloco E, Rua São João Batista 187, sala 428, Centro, Niteroi, RJ, CEP 24020-005, Brazil.ORCID https://orcid.org/0000-0002-5213-0363
Matheus Figueiredo SathlerDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.ORCID https://orcid.org/0000-0003-3928-0751
Danielle Dias Pinto FerreiraLaboratório de Doenças Neurodegenerativas, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Maurício Dos Santos PereiraLaboratório de Neurofisiologia Molecular, Departamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-9012-7379
Ney Ronner PeccinalliLaboratório de Neurofarmacologia, Instituto Biomédico - Bloco E, Rua São João Batista 187, sala 428, Centro, Niteroi, RJ, CEP 24020-005, Brazil.
Pablo PandolfoLaboratório de Neurobiologia do Comportamento Animal, Instituto de Biologia, Universidade Federal Fluminense, Niteroi, Brazil.ORCID https://orcid.org/0000-0002-8039-7698
Ricardo Augusto de Melo ReisLaboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-9689-4085
Gustavo Costa FerreiraLaboratório de Neuroenergética e Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-2892-8842
Alex Christian ManhãesLaboratório de Neurofisiologia, Instituto de Biologia, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-4629-8343
Instituto Biológico · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BRColorado State University · USUniversidade de São Paulo · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cocaine (COC) is a psychostimulant that acts by increasing catecholaminergic neurotransmission mainly due to its effects on the dopamine transporter (DAT). However, other neurotransmitter systems may also be regulated by COC, including the GABAergic system. Since the effect of COC in modulating gamma-aminobutyric acid (GABA) reuptake is not defined, we investigated the molecular mechanisms related to the increase in GABA uptake induced by acute COC exposure and its effects on locomotor activity in adolescent mice. Behavioral experiments showed that COC increased locomotor activity and decreased immobilization time in mice. A single COC exposure reduced both GABA uptake and GAT-1 protein levels. On the other hand, cyclic adenosine monophosphate (cAMP) levels increased after a COC challenge. The major changes induced by acute COC on behavioral and neurochemical assays were avoided by previous treatment with the selective D

Indexed as

AnimalsCentral Nervous System StimulantsCocaineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsFrontal Lobegamma-Aminobutyric AcidMiceMotor ActivitySynaptic TransmissionCentral Nervous System StimulantsCocaineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake Inhibitorsgamma-Aminobutyric AcidCocaineD1-like receptorsGABAGAT-1Mice

Identifiers

PMID32696437
OpenAlexW3045479206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.