Evidence map›Paper›PMID 32696422›Full record

ArticleTransgenic research2020

Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.

Jinfeng Yu, Jiale Dong, Kangdi Chen, Yaping Ding, Zhicheng Yang, Tian Lan

Abstract read
PubMed Publisher
In one paragraph

Article in Transgenic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jinfeng YuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Jiale DongSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Kangdi ChenSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Yaping DingSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Zhicheng YangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Tian LanSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China. lantian012345@163.com.ORCID 0000-0002-5783-6883
Guangdong Pharmaceutical University · CNGuangzhou University of Chinese Medicine · CN

Funding

Innovation and Entrepreneurship Project of Guangdong Pharmaceutical University (CN) 20180573053
6 · The paper itself

Abstract

SphK1 gene has different roles in various types of cells in liver diseases, but most studies are based on global knockout mice, which hampers the study on the cellular and molecular mechanisms of SphK1. In order to further study the role of SphK1 in liver, SphK1 conditional knockout mice were constructed. A liver-specific SphK1 gene knockout mouse model was constructed by the Cre/Loxp recombinant enzyme system. PCR technologies and western blotting were used to identified the elimination of SphK1 gene in hepatocytes. SphK1

Indexed as

AnimalsHepatocytesIntegrasesLysophospholipidsMiceMice, Inbred C57BLMice, KnockoutPhosphotransferases (Alcohol Group Acceptor)SphingosineSphingosine KinaseCre recombinaseIntegrasesLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Sphingosinesphingosine 1-phosphateSphingosine KinaseSphk1 protein, mouseCre/Loxp recombinase systemGenotypingLiver conditional knockoutSphingosine kinase 1

Identifiers

PMID32696422
OpenAlexW3045248955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.