Evidence map›Paper›PMID 32696414›Full record

ArticleJournal of ultrasound2021

The Adoption of Radiomics and machine learning improves the diagnostic processes of women with Ovarian MAsses (the AROMA pilot study).

Valentina Chiappa, Giorgio Bogani, Matteo Interlenghi, Christian Salvatore, Francesca Bertolina, Giuseppe Sarpietro, Mauro Signorelli, Isabella Castiglioni, Francesco Raspagliesi

Open access · greenAbstract read
In one paragraph

Article in Journal of ultrasound, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Application of artificial intelligence to ultrasound imaging for benign gynecological disorders: systematic review.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Pooled it
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  8. Review
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  10. Radiomics-based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
  11. Developing and validating ultrasound-based machine-learning models incorporating radiomics features to predict malignancy in adnexal masses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
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  19. Radiomics analysis of ultrasound images to discriminate between benign and malignant adnexal masses with solid morphology on ultrasound.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Valentina ChiappaDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy. valentina.chiappa@gmail.com.ORCID http://orcid.org/0000-0002-1811-209X
Giorgio BoganiDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.ORCID http://orcid.org/0000-0001-8373-8569
Matteo InterlenghiInstitute of Molecular Bioimaging and Physiology, National Research Council, Segrate, Milan, Italy.ORCID http://orcid.org/0000-0002-3066-4276
Christian SalvatoreDeepTrace Technologies S.R.L., Milan, Italy.ORCID http://orcid.org/0000-0001-9312-4675
Francesca BertolinaDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.ORCID http://orcid.org/0000-0002-3127-2477
Giuseppe SarpietroDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.ORCID http://orcid.org/0000-0003-4891-9000
Mauro SignorelliDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.ORCID http://orcid.org/0000-0002-5568-5233
Isabella CastiglioniDipartimento di Fisica G. Occhialini, University of Milan-Bicocca, Milan, Italy.ORCID http://orcid.org/0000-0001-7191-5417
Francesco RaspagliesiDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.ORCID http://orcid.org/0000-0001-8953-1657
Fondazione IRCCS Istituto Nazionale dei Tumori · ITInstitute of Molecular Bioimaging and Physiology · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop and evaluate the performance of a radiomic and machine learning model applied to ultrasound images in predicting the risk of malignancy of ovarian masses (OMs).

methodsSingle-center retrospective evaluation of consecutive patients who underwent transvaginal ultrasound (US) with images storage and surgery for ovarian masses. Radiomics methodology was applied to US images according to the International Biomarker Standardization Initiative guidelines. OMs were divided into three homogeneous groups: solid, cystic and motley. TRACE4

resultsA total of 241 women were recruited. OMs were divided in the three groups: 95 (39.5%) solid, 66 (27.5%) cystic, 80 (33%) motley. For solid OMs, 269 radiomic features were used for the training-validation-testing of the model with accuracy 80%, sensitivity 78%, specificity 83%, AUC 87%. For cystic OMs, 278 radiomic features were used for the training-validation-testing of the model with accuracy 87%, sensitivity 75%, specificity 90%, AUC 88%. For mixed OMs, 306 radiomic features were used for the training-validation-testing of the model with accuracy 81%, sensitivity 81%, specificity 81%, AUC 89%.

conclusionRadiomics is a promising tool in improving preoeprative work-up of women diagnosed with OMs. Even in the absence of the subjective impression of expert ultrasound examiner, radiomics allows to easily identify patients with ovarian cancer. Future validation studies on larger series are needed.

Indexed as

OdorantsOvarian NeoplasmsFemaleHumansMachine LearningPilot ProjectsRetrospective StudiesOvarian cancerOvarian massesPredictive modelRadiomicsRisk of malignancyUltrasound

Identifiers

PMID32696414
PMCPMC8572235
OpenAlexW3044985529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.