ArticleAnnals of surgical oncology2021
Extended Resections for Advanced Gallbladder Cancer: Results from a Nationwide Cohort Study.
Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Prognostic Value of Perioperative Inflammatory-Immune-Nutritional Indicators in Advanced Gallbladder Cancer.Cancer medicine · 2026Article
- Association of surgical extent with survival in locally advanced gallbladder cancer based on propensity score matching.Scientific reports · 2026Article
- Review
- Performance of major liver resection for gallbladder cancer-a western retrospective single center cohort study.Hepatobiliary surgery and nutrition · 2025Article
- Role of Portal Vein Embolization Alone in Surgical Management of Locally Advanced Gall Bladder Cancer (PROVE-GBC): A Prospective Clinical Trial.Indian journal of surgical oncology · 2025Article
- Prognostic Factors and Treatment Outcomes in Gallbladder Cancer Patients Undergoing Curative Surgery: A Multicenter Retrospective Cohort Study.Current oncology (Toronto, Ont.) · 2025Article
- Optimal timing for cholecystectomy: unveiling insights from a decade-long study on acute cholecystitis and symptomatic cholecystolithiasis.BMC surgery · 2025Article
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- Comparison of treatment models for single primary advanced gallbladder cancer.Frontiers in immunology · 2024Article
- Unraveling the Mysteries of Perineural Invasion in Benign and Malignant Conditions.Current oncology (Toronto, Ont.) · 2023Review
- Improved long-term outcomes after innovative preoperative evaluation and conception of precise surgery for gallbladder cancer.Cancer medicine · 2023Article
- Radical surgery for stage IV gallbladder cancers: Treatment strategies in patients with limited metastatic burden.Annals of hepato-biliary-pancreatic surgery · 2023Article
- Survival after extended resections for gallbladder cancer.Annals of hepato-biliary-pancreatic surgery · 2023Article
- Gallbladder cancer: current and future treatment options.Frontiers in pharmacology · 2023Review
- Preoperative Assessment and Perioperative Management of Resectable Gallbladder Cancer in the Era of Precision Medicine and Novel Technologies: State of the Art and Future Perspectives.Diagnostics (Basel, Switzerland) · 2022Review
- The clinical outcomes of extended resections in patients with IV stage gallbladder cancers: A retrospective study from a large tertiary center.Frontiers in oncology · 2022Article
- Insights From the Analysis of Clinicopathological and Prognostic Factors in Patients With Gallbladder Cancer.Frontiers in oncology · 2022Article
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtended resections (i.e., major hepatectomy and/or pancreatoduodenectomy) are rarely performed for gallbladder cancer (GBC) because outcomes remain inconclusive. Data regarding extended resections from Western centers are sparse. This Dutch, multicenter cohort study analyzed the outcomes of patients who underwent extended resections for locally advanced GBC.
methodsPatients with GBC who underwent extended resection with curative intent between January 2000 and September 2018 were identified from the Netherlands Cancer Registry. Extended resection was defined as a major hepatectomy (resection of ≥ 3 liver segments), a pancreatoduodenectomy, or both. Treatment and survival data were obtained. Postoperative morbidity, mortality, survival, and characteristics of short- and long-term survivors were assessed.
resultsThe study included 33 patients. For 16 of the patients, R0 resection margins were achieved. Major postoperative complications (Clavien Dindo ≥ 3A) occurred for 19 patients, and 4 patients experienced postoperative mortality within 90 days. Recurrence occurred for 24 patients. The median overall survival (OS) was 12.8 months (95% confidence interval, 6.5-19.0 months). A 2-year survival period was achieved for 10 patients (30%) and a 5-year survival period for 5 patients (15%). Common bile duct, liver, perineural and perivascular invasion and jaundice were associated with reduced survival. All three recurrence-free patients had R0 resection margins and no liver invasion.
conclusionThe median OS after extended resections for advanced GBC was 12.8 months in this cohort. Although postoperative morbidity and mortality were significant, long-term survival (≥ 2 years) was achieved in a subset of patients. Therefore, GBC requiring major surgery does not preclude long-term survival, and a subgroup of patients benefit from surgery.
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