Evidence map›Paper›PMID 32696284›Full record

ArticleJournal of clinical immunology2020

Successful Matched Related Bone Marrow Transplantation in a Patient with Autosomal Dominant Interferon Gamma Receptor 1 Deficiency.

Christa S Zerbe, Dimana Dimitrova, Juan J Gea-Banacloche, Samantha Kreuzburg, Steven M Holland, Jennifer A Kanakry

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christa S ZerbeLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. zerbech@niaid.nih.gov.ORCID 0000-0003-4219-0503
Dimana DimitrovaExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Juan J Gea-BanaclocheMayo Clinic, Phoenix, AZ, USA.
Samantha KreuzburgLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jennifer A KanakryExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USMayo Clinic Hospital · US

Funding

Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
6 · The paper itself

Abstract

This is a report of a successful bone marrow transplant in an IFN-γR1 patient with progressive mycobacterial infection. PURPOSE: Hematopoietic cell transplant in patients with interferon gamma receptor deficiencies has been fraught with challenges, not the least of which is failure of engraftment and infectious complications.

methodsThis is a report of a successful hematopoietic cell transplant in an actively infected patient of advanced age.

resultsThis case report shows successful engraftment and resolution of infection posttransplant using a matched related donor in a single institution.

conclusionA successful curative HCT despite persistent, disseminated, nontuberculous mycobacterial infection in a patient with AD-IFNγR1 suggests that this approach, while difficult, may be useful in other patients with otherwise refractory disease.

Indexed as

Bone Marrow TransplantationGenes, DominantGenetic Association StudiesGenetic Predisposition to DiseaseHematopoietic Stem Cell TransplantationHumansInterferon gamma ReceptorMycobacterium InfectionsMycobacterium Infections, NontuberculousReceptors, InterferonSeverity of Illness IndexTransplantation, HomologousTreatment OutcomeInterferon gamma ReceptorReceptors, Interferonhematopoietic cell transplantinfectionInterferon gamma receptornontuberculous mycobacteria

Identifiers

PMID32696284
OpenAlexW3045432510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.