Trial reportClinical oral investigations2021
Adhesive restoration of molars affected by molar incisor hypomineralization: a randomized clinical trial.
Trial report in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Restorative interventions and management of primary and permanent molars affected by molar incisor hypo-mineralization: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Evidence mapping and quality assessment of randomised trials related to molar incisor hypomineralisation.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- Management strategies for posterior deciduous and permanent teeth with developmental defects of enamel presenting post-eruptive breakdown or atypical cavitated carious lesions: systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- Desensitization treatment in MIH-affected teeth: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- Pretreatments to bonding on enamel and dentin disorders: a systematic review.Evidence-based dentistry · 2024Pooled it
- An update of treatment modalities in children and adolescents with teeth affected by molar incisor hypomineralisation (MIH): a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Can molar incisor hypomineralization cause dental fear and anxiety or influence the oral health-related quality of life in children and adolescents?-a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Effects of different remineralization agents on MIH defects: a randomized clinical study.Clinical oral investigations · 2022Trial
- Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial.Clinical oral investigations · 2022Trial
- Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial.Journal of applied oral science : revista FOB · 2022Trial
- Comparison of different cavity patterns and treatment methods in molars with molar-incisor hypomineralization (MIH) - retrospective 9 months results.BMC oral health · 2026Article
- Long-term evaluation of the success rate of different treatment modalities on MIH-affected teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Key concepts for clinical management of Molar Incisor Hypomineralization.Brazilian oral research · 2026Review
- Bonding to Molar-Incisor Hypomineralization Affected Teeth: A Scoping Review of Adhesive Strategies, In Vitro Performance, and Clinical Outcomes.Frontiers in dentistry · 2026Review
- Strategies for Restoration of Compromised First Permanent Molars in Children: Challenges and Optimal Timing.Oral health & preventive dentistry · 2025Review
- Six-year survival and clinical performance of glass hybrid restorations following selective caries removal in teeth with molar incisor hypomineralization: a prospective cohort study.Clinical oral investigations · 2025Article
- Review
- Article
- A clinical investigation comparing the efficacy of composite resin vs. resin-infiltrated ceramic CAD/CAM onlays for restoring permanent first molars affected by severe molar-incisor hypomineralization.Frontiers in dental medicine · 2025Article
- Perceptions, attitudes, and clinical experiences of Brazilian dental practitioners towards molar incisor hypomineralisation: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis randomized clinical trial evaluated the survival of direct restorations on first permanent molars (FPMs) with molar incisor hypomineralization (MIH) and its impact on self-reported dental pain and dental anxiety. MATERIAL AND
methodFPMs with MIH of 35 patients aged 7 to 16 years were included. The FPMs were randomized into the following two groups: total-etch (TE-37% phosphoric acid etching) and self-etch (SE-no prior etching). The FPMs were restored with universal adhesive and bulk-fill resin composites. The restoration survival was evaluated according to USPHS criteria modified by a blinded examiner. Dental anxiety (Venham picture test) and dental pain (Faces pain scale-revised) were evaluated before treatment and at 1, 6, and 12 months post-treatment. Survival rates were analyzed by the Kaplan-Meier method and the log-rank test. Nonparametric tests compared pain and anxiety in the follow-up periods.
resultsA total of 64 FPMs were restored (TE = 33; SE = 31). Survival rates were 96.9% (TE) and 96.7% (SE) after 1 month, 90.5% (TE) and 80.6% (SE) after 6 months, and 80.8% (TE) and 62.3% (SE) after 12 months (p > 0.05). Self-reported dental pain and anxiety level decreased after treatment in both groups (p < 0.05). Self-reported pain decreased after 1 month in SE, but it occurred at 6 months in TE.
conclusionBoth restorative protocols presented similar longevity, decreasing self-reported pain and anxiety levels. CLINICAL RELEVANCE: A universal adhesive could be appropriate for restoration of MIH-affected teeth, and the survival of restorations could be higher in the total-etch technique, reducing dental pain and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.