ReviewCritical care explorations2020
Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce.
Review in Critical care explorations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Septic Shock and Prognosis in Dogs and Cats With Sepsis-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Feasibility of Enteral Nutrition in Pediatric Septic Shock at a Tertiary Center in Vietnam.Indian journal of pediatrics · 2026Observational
- Accurate prediction of mortality in children with sepsis: development and validation of an explainable model based on real-world data.Italian journal of pediatrics · 2026Article
- Procalcitonin for Predicting Sepsis in Infants in the Emergency Department: A Retrospective Study.Pediatric health, medicine and therapeutics · 2026Article
- Review
- The 2024 Phoenix Sepsis Score Criteria: Part 1, the Evolution in Definition of Sepsis and Septic Shock.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- Article
- Sepsis epidemiology in AustralBMJ open · 2024Article
- Reporting of social determinants of health in randomized controlled trials conducted in the pediatric intensive care unit.Frontiers in pediatrics · 2024Article
- Clinical decision support tools for paediatric sepsis in resource-poor settings: an international qualitative study.BMJ open · 2023Article
- Extracorporeal Membrane Oxygenation for Septic Shock in Adults and Children: A Narrative Review.Journal of clinical medicine · 2023Review
- Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children.Journal of pediatric intensive care · 2023Article
- Article
- Pediatric Sepsis: a Summary of Current Definitions and Management Recommendations.Current pediatrics reports · 2023Review
- Identification of sepsis in paediatric emergency departments: A scoping review.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Predictors of postoperative systemic inflammatory response syndrome after scoliosis surgery in adolescents with cerebral palsy: A retrospective analysis.North American Spine Society journal · 2022Article
- Impact of an electronic alert system for pediatric sepsis screening a tertiary hospital experience.Scientific reports · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
objectivesSepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term "sepsis" in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine's Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death. DATA SOURCES: We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. STUDY SELECTION: We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020. DATA EXTRACTION: Data extraction will include information related to study characteristics, population characteristics, clinical criteria, and outcomes. DATA SYNTHESIS: We will calculate sensitivity and specificity of each criterion for predicting sepsis and conduct a meta-analysis if the data allow. We will also provide pooled estimates of overall hospital mortality.
conclusionsThe potential risk factors, clinical criteria, and illness severity scores from this review which identify patients with infection who are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death will be used to inform the next steps of the Pediatric Sepsis Definition Taskforce.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.